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LSKL, Inhibitor of Thrombospondin TSP-1 2TFA

LSKL, Inhibitor of Thrombospondin TSP-1 2TFA
LSKL, Inhibitor of Thrombospondin TSP-1 2TFA is activation of TGF-β .
Catalog No. T7676
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LSKL, Inhibitor of Thrombospondin TSP-1 2TFA

Catalog No. T7676

LSKL, Inhibitor of Thrombospondin TSP-1 2TFA is activation of TGF-β .
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$45In Stock
2 mg$62In Stock
5 mg$86In Stock
10 mg$135In Stock
25 mg$248In Stock
50 mg$381In Stock
100 mg$587In Stock
1 mL x 10 mM (in DMSO)$148In Stock
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Product Introduction

Bioactivity
Description
LSKL, Inhibitor of Thrombospondin TSP-1 2TFA is activation of TGF-β .
In vivo
Administration of LSKL peptide attenuated Smad2 phosphorylation at 6 h. S-phase entry of hepatocytes was accelerated at 24 and 48 h by LSKL peptide, which resulted in faster recovery of the residual liver and bodyweight.?Haematoxylin and eosin tissue staining and blood biochemical examinations revealed no significant adverse effects following the two LSKL peptide administrations.?In the clinical setting, plasma TSP-1 levels were lowest on the first day after hepatectomy.?However, plasma TSP-1 levels at this stage were significantly higher in patients with subsequent liver dysfunction compared with levels in those without liver dysfunction following hepatectomy
Animal Research
Mice were operated on with a 70 per cent hepatectomy or sham procedure. Operated mice received either LSKL peptide or normal saline intraperitoneally at abdominal closure and 6 h after hepatectomy. Perioperative plasma TSP-1 levels were measured by enzyme-linked immunosorbent assay in patients undergoing hepatectomy.
AliasLSKL, Inhibitor of Thrombospondin TSP-1
Chemical Properties
Molecular Weight686.64
FormulaC25H44F6N6O9
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 27.5 mg/mL (40.05 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.4564 mL7.2818 mL14.5637 mL72.8184 mL
5 mM0.2913 mL1.4564 mL2.9127 mL14.5637 mL
10 mM0.1456 mL0.7282 mL1.4564 mL7.2818 mL
20 mM0.0728 mL0.3641 mL0.7282 mL3.6409 mL

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