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Fulvene-5

Catalog No. T11333 CAS 1075723-01-1

Fulvene-5 is a chemical compound that exhibits antitumor activity. It functions as a potent inhibitor of NADPH oxidase 4 (NOX4) and possesses antioxidant properties. Additionally, Fulvene-5 acts as a reactive oxygen species (ROS) modifying agent and a powerful radioprotector.

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Fulvene-5, CAS 1075723-01-1

Pack Size	Availability	Price/USD	Quantity
25 mg	6-8 weeks	$ 1,980.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

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Description	Fulvene-5 is a chemical compound that exhibits antitumor activity. It functions as a potent inhibitor of NADPH oxidase 4 (NOX4) and possesses antioxidant properties. Additionally, Fulvene-5 acts as a reactive oxygen species (ROS) modifying agent and a powerful radioprotector.
In vitro	Fulvene-5, administered at concentrations of 0.5-1.0 μM, significantly reduces the levels of Ang2, delta-like ligand 4 (DLL4), placental growth factor (PLGF), and Nrarp in bEnd.3 cells in a dose-dependent fashion. At a higher concentration (10?μM for 1 hour), Fulvene-5 shifts the adaptive responses of HCT116 TP53 wild type (WT) and HCT116 isogenic TP53 null mutant (Mut) cell cultures from promoting survival towards enhancing sensitivity to radiation, and inversely. These alterations coincide with the moving of survivin into the nuclei in TP53 WT cells and out to the cytoplasm in TP53 Mut cells. Additionally, the involvement of NOX4 in survivin-related adaptive responses is explored by diminishing NOX4 expression through the transfection of HCT116 cells with NOX4 siRNA oligomers, achieving approximately a 50% reduction in NOX4 expression.
In vivo	Fulvene-5??treatment potently inhibits hemangioma growth in mice.

Molecular Weight	358.43
Formula	C26H18N2
CAS No.	1075723-01-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Murley JS, et al. ROS modifiers and NOX4 affect the expression of the survivin-associated radio-adaptive response. Free Radic Biol Med. 2018 Aug 1;123:39-52. 2. Bhandarkar SS, et al. Fulvene-5 potently inhibits NADPH oxidase 4 and blocks the growth of endothelial tumors in mice. J Clin Invest. 2009 Aug;119(8):2359-65. 3. Weyemi U, et al. Inactivation of NADPH oxidases NOX4 and NOX5 protects human primary fibroblasts from ionizing radiation-induced DNA damage. Radiat Res. 2015 Mar;183(3):262-70.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Fulvene-5 1075723-01-1 Others Fulvene5 Fulvene 5 inhibitor inhibit

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