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Metabolism Vitamin Coumetarol

Coumetarol

Catalog No. T10867   CAS 4366-18-1
Synonyms: Dicumoxane, Ph 137

Coumetarol is an antagonist of vitamin K.

Coumetarol, CAS 4366-18-1
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Purity 98.00%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Coumetarol is an antagonist of vitamin K.
Targets&IC50 vitamin K,  
In vitro The vitamin K antagonist Coumetarol (Dicumoxane) is effective in both models after oral treatment but inhibits thrombus formation more strongly in the arterio-venous shunt model. Treatment with Coumetarol in a dose of 25 mg/kg p.o. twice daily for 2 days results in a significant reduction in thrombus weight by 50% in the venous stasis model and by 75% in the arterio-venous shunt model. In both experiments, the coagulation time as measured by the Thrombotest is prolonged to the same extent.
Synonyms Dicumoxane , Ph 137
Purity 98.00%
Molecular Weight 380.35
Formula C21H16O7
CAS No. 4366-18-1

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Vogel GM, et al. Comparison of two experimental thrombosis models in rats effects of four glycosaminoglycans. Thromb Res. 1989 Jun 1;54(5):399-410.

Related Products

Related compounds with same targets
Paricalcitol Beta-Carotene Calcipotriol Ercalcitriol Coumetarol Acenocoumarol Calcipotriol monohydrate Menatetrenone

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