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Cetrorelix Acetate

Catalog No. T5520 CAS 145672-81-7

Synonyms: Cetrorelix

Cetrorelix Acetate is gonadotropin-releasing hormone (GnRH) receptor antagonist with an IC50 of 1.21 nM.

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Cetrorelix Acetate, CAS 145672-81-7

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Cetrorelix Acetate is gonadotropin-releasing hormone (GnRH) receptor antagonist with an IC50 of 1.21 nM.
Targets&IC50	GnRH:1.21 nM
In vitro	GnRH-I antagonist Cetrorelix inhibited growth of ES-2 cell line only at 1000 ng/ml.?The incubation of ES-2 ovarian cancer cells in vitro with an GnRH-I antibody inhibited cell proliferation in a time and concentration-dependent manner.?GnRH-I may function as an autocrine growth factor in this ovarian cancer cell line [1].
In vivo	Cetrorelix inhibits the activation of hGnRHR and a downstream luciferase reporter gene in murine LTK- cells by the GnRHR agonist [D-Trp6]GnRH (IC50 = 1.2 nM). In vivo, cetrorelix (60 μg per day) reduces tumor volume to 35% of control and decreases serum luteinizing hormone levels by 50% in a human epithelial ovarian cancer mouse xenograft model[2].

Synonyms	Cetrorelix
Molecular Weight	1491.11
Formula	C70H92ClN17O14.C2H4O2
CAS No.	145672-81-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 50 mg/mL (33.53 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Gründker, Carsten, Emons, Günter. Role of gonadotropin-releasing hormone (GnRH) in ovarian cancer[J]. Reproductive Biology & Endocrinology Rb & E, 2003, 1(1):65-65. 2. Yano T , Pinski J , Halmos G , et al. Inhibition of growth of OV-1063 human epithelial ovarian cancer xenografts in nude mice by treatment with luteinizing hormone-releasing hormone antagonist SB-75.[J]. Proceedings of the National Academy of Sciences, 1994, 91(15):7090-7094.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Cetrorelix Acetate 145672-81-7 GPCR/G Protein GNRH Receptor SB-75 GnRH Receptor Inhibitor SB 75 Gonadotropin releasing hormone receptor inhibit SB75 GNRHR Cetrorelix inhibitor

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