Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cercosporamide is a ATP-competitive Pkc1 kinase inhibitor (IC50 <50 nM; Ki <7 nM). It also is a unique Mnk inhibitor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | 6-8 weeks | $ 1,560.00 |
Description | Cercosporamide is a ATP-competitive Pkc1 kinase inhibitor (IC50 <50 nM; Ki <7 nM). It also is a unique Mnk inhibitor. |
Targets&IC50 | MNK:50 nM, PKC1:50 nM, PKC1:7 nM (ki) |
In vitro | Cercosporamide is a broad-spectrum natural antifungal compound and a selective and highly potent fungal Pkc1 kinase inhibitor [1]. Cercosporamide is recently shown to act as a unique Mnk inhibitor with antileukemic properties. Cercosporamide is a potent inhibitor of phosphorylation of eIF4E at Ser209 in AML cells and results in potent inhibitory effects on primitive leukemic progenitors (CFU-L) from AML patients. When U937 cells are incubated in the presence or absence of the increasing doses of Cercosporamide, dose-dependent suppression of cell growth is found. Similar experiments with comparable results are seen when the effects of Cercosporamide on MM6 and K562 cells are examined [2]. |
In vivo | Treatment with either Cercosporamide or Ara-C alone markedly inhibits xenograft growth compared to their respective controls, achieving statistical significance (P<0.011 for 10 mg/kg Cercosporamide twice-daily; P<0.006 for 20 mg/kg Cercosporamide daily; P<0.0374 for Ara-C). The combined application of Cercosporamide (10 mg/kg twice daily) with Ara-C substantially enhances efficacy beyond that of either compound used singly. Similarly, the synergy of Cercosporamide (20 mg/kg daily) with Ara-C markedly reduces tumor growth compared to both captisol (P<0.0001) and water controls (P=0.0003), albeit without significant superiority over the individual effects of either Cercosporamide (20 mg/kg) or Ara-C alone. |
Synonyms | (-)-Cercosporamide |
Molecular Weight | 331.28 |
Formula | C16H13NO7 |
CAS No. | 131436-22-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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Cercosporamide 131436-22-1 Others (-)-Cercosporamide inhibitor inhibit