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Carbobenzoxyphenylalanine

Catalog No. T20485 CAS 1161-13-3

Synonyms: NSC 402059, NSC402059, NSC-402059, Carbobenzoxy-L-phenylalanine

Carbobenzoxyphenylalanine (NSC-402059) is a thermolysin inhibitor.

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Carbobenzoxyphenylalanine Chemical Structure

Carbobenzoxyphenylalanine, CAS 1161-13-3

Pack Size	Availability	Price/USD	Quantity
1 g	In stock	$ 29.00
1 mL * 10 mM (in DMSO)	In stock	$ 45.00

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Purity: 99.71%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Carbobenzoxyphenylalanine (NSC-402059) is a thermolysin inhibitor.

In vitro

The protease can be inhibited by the serine specific reagents phenylmethanesulfonyl fluoride and diisopropyl fluorophosphate and the alkylating reagent, carbobenzoxyphenylalanine chloromethyl ketone, in the presence of organic solvents at 1 mM concentration.?The inhibitions of chromatin-bound protease in rat liver by these compounds are irreversible.?On the other hand, carbobenzoxyphenylalanine and p-nitrophenyl acetate were shown to be reversible inhibitors of rat liver chromatin-bound protease[1].

Synonyms	NSC 402059, NSC402059, NSC-402059, Carbobenzoxy-L-phenylalanine
Molecular Weight	299.32
Formula	C17H17NO4
CAS No.	1161-13-3

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/ml (200.45 mM)

References and Literature

1. Carter DB, Chae CB. Chromatin-bound protease: degradation of chromosomal proteins under chromatin dissociation conditions. Biochemistry. 1976 Jan 13;15(1):180-5. PubMed PMID: 2280. 2. Jany K D , Haug H , Pfleiderer G , et al. Enzymatic and chemical properties of an endopeptidase from the larva of the hornet Vespa crabro.[J]. Biochemistry, 1978, 17(22). 3. Ceruso M, Howe N, Malthouse JP. Mechanism of the binding of Z-L-tryptophan and Z-L-phenylalanine to thermolysin and stromelysin-1 in aqueous solutions. Biochim Biophys Acta. 2012 Feb;1824(2):303-10. doi: 10.1016/j.bbapap.2011.10.007. Epub 2011 Oct 19. PubMed PMID: 22037182.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compound Library Bioactive Compounds Library Max NO PAINS Compound Library Protease Inhibitor Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Carbobenzoxyphenylalanine 1161-13-3 Others Inhibitor NSC 402059 inhibit NSC402059 NSC-402059 Carbobenzoxy-L-phenylalanine inhibitor

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