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Atrimustine

Catalog No. T14344   CAS 75219-46-4
Synonyms: KM2210, Bestrabucil

Atrimustine is a conjugate of chlorambucil and β-estradiol benzoate. It has the antitumor activity.

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Atrimustine Chemical Structure
Atrimustine, CAS 75219-46-4
Pack Size Availability Price/USD Quantity
5 mg 6-8 weeks $ 249.00
50 mg 6-8 weeks $ 1,190.00
100 mg 6-8 weeks $ 1,860.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Atrimustine is a conjugate of chlorambucil and β-estradiol benzoate. It has the antitumor activity.
In vitro Atrimustine (Bestrabucil) is a conjugate of chlorambucil and β-estradiol benzoate. Which has high affinity for tumor cells and enhances the antitumor activity of chlorambucil[1]. At Atrimustine concentrations of 100 nM-10 μM, concentration-dependent inhibition of growth factor production by SC-115 cells can be demonstrated by 3H-thymidine uptake assay[2]. The effect of Atrimustine (Bestrabucil), a benzoate of an estradiol-chlorambucil conjugate, is examined on the production of growth factor(s) by Shionogi carcinoma 115 (SC-115) cells, an androgen-responsive cultured cancer cell line.
Synonyms KM2210, Bestrabucil
Molecular Weight 720.72
Formula C41H47Cl2NO6
CAS No. 75219-46-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Ezaki K, et al. A combination trial of human lymphoblastoid interferon and bestrabucil (KM2210) for adult T-cell leukemia-lymphoma. Cancer. 1991 Aug 15;68(4):695-8. 2. Akaza H, et al. Inhibitory effects of bestrabucil, a conjugate of chlorambucil and estradiol, on the production of androgen-induced growth factor(s) by Shionogi carcinoma 115 cells. Int J Urol. 1994 Mar;1(1):67-73.

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Keywords

Atrimustine 75219-46-4 Others KM 2210 KM2210 KM-2210 Bestrabucil inhibitor inhibit

 

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