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AS2521780

Catalog No. T14328 CAS 1214726-89-2

AS2521780 is an inhibitor of <a href="/target/PKC" style="display: inline; color: #c13a36">PKC</a>θ (IC50: 0.48 nM).

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AS2521780, CAS 1214726-89-2

Pack Size	Availability	Price/USD
5 mg	14-16 weeks	$ 1,870.00
50 mg	14-16 weeks	$ 3,780.00
100 mg	14-16 weeks	$ 5,200.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	AS2521780 is an inhibitor of PKCθ (IC50: 0.48 nM).
Targets&IC50	PKCα:160 nM, PKCδ:160 nM, PKCθ:0.48 nM, PKCε:18 nM
In vitro	AS2521780 suppresses CD3/CD28-induced Interleukin-2 (IL-2) gene transcription in Jurkat T cells and proliferation of human primary T cells and it also suppresses concanavalin A-induced cytokine production by rat splenocytes and monkey peripheral blood mononuclear cells with similar potency[1]. AS2521780 exerts potent inhibition of recombinant human PKCθ enzyme activity (IC50=0.48 nM). Which is more than 30-fold higher than that of other PKC isoforms. Further, AS2521780 exerts little or no inhibition on other protein kinases.
In vivo	AS2521780 significantly reduces paw swelling in a dose-dependent manner in a rat model of adjuvant-induced arthritis[1].

Molecular Weight	547.77
Formula	C30H41N7OS
CAS No.	1214726-89-2

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Fukahori H, et al. Effect of AS2521780, a novel PKCθ selective inhibitor, on T cell-mediated immunity. Eur J Pharmacol. 2014 Dec 15;745:217-22.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

AS2521780 1214726-89-2 Chromatin/Epigenetic Cytoskeletal Signaling PKC AS-2521780 Inhibitor inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.