Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AS2521780 is an inhibitor of PKCθ (IC50: 0.48 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 10-14 weeks | $ 2,870.00 | |
50 mg | 10-14 weeks | $ 3,780.00 | |
100 mg | 10-14 weeks | $ 5,200.00 |
Description | AS2521780 is an inhibitor of PKCθ (IC50: 0.48 nM). |
Targets&IC50 | PKCα:160 nM, PKCδ:160 nM, PKCθ:0.48 nM, PKCε:18 nM |
In vitro | AS2521780 effectively inhibits CD3/CD28-induced Interleukin-2 (IL-2) gene transcription in Jurkat T cells and the proliferation of human primary T cells. Additionally, it impedes concanavalin A-induced cytokine production in rat splenocytes and monkey peripheral blood mononuclear cells with comparable efficacy[1]. The compound demonstrates a potent inhibition of recombinant human PKCθ enzyme activity, with an IC50 value of 0.48 nM, showcasing more than a 30-fold selective inhibition over other PKC isoforms. Moreover, AS2521780 exhibits minimal or no inhibitory effects on other protein kinases. |
In vivo | AS2521780 markedly diminishes paw swelling through a dose-dependent mechanism in a rat model of adjuvant-induced arthritis[1]. |
Molecular Weight | 547.76 |
Formula | C30H41N7OS |
CAS No. | 1214726-89-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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AS2521780 1214726-89-2 Chromatin/Epigenetic Cytoskeletal Signaling PKC AS 2521780 AS-2521780 inhibitor inhibit