Powder: -20°C for 3 years
In solvent: -80°C for 2 years
AS2521780 is an inhibitor of <a href="/target/PKC" style="display: inline; color: #c13a36">PKC</a>θ (IC50: 0.48 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | 14-16 weeks | $ 1,870.00 | |
50 mg | 14-16 weeks | $ 3,780.00 | |
100 mg | 14-16 weeks | $ 5,200.00 |
Description | AS2521780 is an inhibitor of PKCθ (IC50: 0.48 nM). |
Targets&IC50 | PKCα:160 nM, PKCδ:160 nM, PKCθ:0.48 nM, PKCε:18 nM |
In vitro | AS2521780 suppresses CD3/CD28-induced Interleukin-2 (IL-2) gene transcription in Jurkat T cells and proliferation of human primary T cells and it also suppresses concanavalin A-induced cytokine production by rat splenocytes and monkey peripheral blood mononuclear cells with similar potency[1]. AS2521780 exerts potent inhibition of recombinant human PKCθ enzyme activity (IC50=0.48 nM). Which is more than 30-fold higher than that of other PKC isoforms. Further, AS2521780 exerts little or no inhibition on other protein kinases. |
In vivo | AS2521780 significantly reduces paw swelling in a dose-dependent manner in a rat model of adjuvant-induced arthritis[1]. |
Molecular Weight | 547.77 |
Formula | C30H41N7OS |
CAS No. | 1214726-89-2 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
AS2521780 1214726-89-2 Chromatin/Epigenetic Cytoskeletal Signaling PKC AS-2521780 Inhibitor inhibitor inhibit