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(S,R,S)-AHPC-PEG4-N3

Catalog No. T17921 CAS 1797406-81-5

Synonyms: VH032-PEG4-N3, VHL Ligand-Linker Conjugates 5, E3 ligase Ligand-Linker Conjugates 4

(S,R,S)-AHPC-PEG4-N3 (VHL Ligand-Linker Conjugates 5) is a synthesized conjugate that functions as a ligand-linker in E3 ligase-based systems. It is composed of the (S,R,S)-AHPC VHL ligand and a 4-unit PEG linker, both commonly employed in PROTAC technology.

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(S,R,S)-AHPC-PEG4-N3, CAS 1797406-81-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 36.00
2 mg	In stock	$ 50.00
5 mg	In stock	$ 83.00
10 mg	In stock	$ 119.00
25 mg	In stock	$ 197.00
50 mg	In stock	$ 296.00
100 mg	In stock	$ 455.00

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Purity: 98.06%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	(S,R,S)-AHPC-PEG4-N3 (VHL Ligand-Linker Conjugates 5) is a synthesized conjugate that functions as a ligand-linker in E3 ligase-based systems. It is composed of the (S,R,S)-AHPC VHL ligand and a 4-unit PEG linker, both commonly employed in PROTAC technology.
In vitro	E3 ligase Ligand-Linker Conjugates 4 together with JQ1 triggers the intracellular destruction of BET proteins[1].

Synonyms	VH032-PEG4-N3, VHL Ligand-Linker Conjugates 5, E3 ligase Ligand-Linker Conjugates 4
Molecular Weight	689.83
Formula	C32H47N7O8S
CAS No.	1797406-81-5

Storage

keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (65.2 mM), Sonication is recommended.

References and Literature

1. Zengerle M, et al. Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4. ACS Chemical Biology (2015), 10(8), 1770-1777.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

(S,R,S)-AHPC-PEG4-N3 1797406-81-5 Others PROTAC PROTAC Linker VH032-PEG4-N3 VHL Ligand-Linker Conjugates 5 E3 ligase Ligand-Linker Conjugates 4 AHPC-PEG4-N3 inhibitor inhibit

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