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(E)-6-O-(p-coumaroyl)scandoside methyl ester

Catalog No. TN6638 CAS 83946-90-1

(E)-6-O-(p-coumaroyl)scandoside methyl ester shows moderate anti-proliferation effect on PC3 human androgen-independent prostate cancer cells.

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(E)-6-O-(p-coumaroyl)scandoside methyl ester Chemical Structure

(E)-6-O-(p-coumaroyl)scandoside methyl ester, CAS 83946-90-1

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Description	(E)-6-O-(p-coumaroyl)scandoside methyl ester shows moderate anti-proliferation effect on PC3 human androgen-independent prostate cancer cells.
In vitro	Baihuasheshecao (Hedyotis diffusa), a Chinese herb for cancer treatment, is frequently adulterated by a related species Hedyotis corymbosa. METHODS AND RESULTS:DNA sequencing of the complete internal transcribed spacer region was applied to differentiate H. diffusa from H. corymbosa and other closely related species. The molecular data showed that four out of seven herb samples of Baihuasheshecao were adulterants. Chemical analyses by TLC and HPLC were used to authenticate H. diffusa and H. corymbosa. Two marker compounds were identified exclusively in H. diffusa: 6-O-(E)-p-coumaroyl scandoside methyl ester ((E)-6-O-(p-coumaroyl)scandoside methyl ester , compound 1) and 10(S)-hydroxypheophytin a (compound 2). Both compounds showed moderate anti-proliferation effect on PC3 human androgen-independent prostate cancer cells, while compound 2 also showed strong anti-proliferation effect on LNCaP human androgen-sensitive prostate cancer cells. CONCLUSIONS: Accordingly, these bioactive marker compounds could be applied to verify the authenticity and assess the quality of Baihuasheshecao.
Source	Natural Products > Rubiaceae > Gardenia

Molecular Weight	550.513
Formula	C26H30O13
CAS No.	83946-90-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Authentication of the anti-tumor herb Baihuasheshecao with bioactive marker compounds and molecular sequences. Food Chemistry, 2010, 119(3):1239-1245.

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Keywords

(E)-6-O-(p-coumaroyl)scandoside methyl ester 83946-90-1 (E) 6 O (p coumaroyl)scandoside methyl ester 6-O-(p-coumaroyl)scandoside methyl ester (E)6O(pcoumaroyl)scandoside methyl ester inhibitor inhibit

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