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(+)-Ketoconazole

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Catalog No. T13464Cas No. 142128-59-4
Alias (+)-R41400, (+)-R 41400, (+)-Ketoconazol

(+)-Ketoconazole ((+)-R 41400) is a broad-spectrum oral antifungal compound, a CYP3A4 inhibitor, used for the study of fungal infections and seborrheic dermatitis.

(+)-Ketoconazole
Other Forms of (+)-Ketoconazole:

(+)-Ketoconazole

🥰Excellent
Purity: 99.79%
Catalog No. T13464Alias (+)-R41400, (+)-R 41400, (+)-KetoconazolCas No. 142128-59-4
(+)-Ketoconazole ((+)-R 41400) is a broad-spectrum oral antifungal compound, a CYP3A4 inhibitor, used for the study of fungal infections and seborrheic dermatitis.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$29-In Stock
10 mg$72-In Stock
1 mL x 10 mM (in DMSO)$69-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.79%
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Product Introduction

Bioactivity
Description
(+)-Ketoconazole ((+)-R 41400) is a broad-spectrum oral antifungal compound, a CYP3A4 inhibitor, used for the study of fungal infections and seborrheic dermatitis.
In vitro
(+)-Ketoconazole, an imidazole derivative, is a broad-spectrum systemic antifungal agent with oral activity that effectively inhibits CYP3A4 activity in human liver microsomes. [1]
In vivo
Perinatal exposure of female rats to (+)-Ketoconazole (3-6-12mg/kg.d), adolescence or adulthood (3-12-48mg/kg.d) showed that perinatal exposure to the highest dose of (+)-Ketoconazole delayed the maturation of GnRH secretion before puberty, while adolescent or adult exposure had no effect on GnRH pulsation. [2]
Synonyms(+)-R41400, (+)-R 41400, (+)-Ketoconazol
Chemical Properties
Molecular Weight531.43
FormulaC26H28Cl2N4O4
Cas No.142128-59-4
SmilesC([C@]1(O[C@@H](COC2=CC=C(C=C2)N3CCN(C(C)=O)CC3)CO1)C4=C(Cl)C=C(Cl)C=C4)N5C=CN=C5
Relative Density.no data available
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 20 mg/mL (37.63 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.76 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.8817 mL9.4086 mL18.8172 mL94.0858 mL
5 mM0.3763 mL1.8817 mL3.7634 mL18.8172 mL
10 mM0.1882 mL0.9409 mL1.8817 mL9.4086 mL
20 mM0.0941 mL0.4704 mL0.9409 mL4.7043 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

(+)Ketoconazole(+) Ketoconazole
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