Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Steroid sulfatase/17β-HSD1-IN-5 serves as an irreversible inhibitor of steroid sulfatase (STS) and a reversible, selective inhibitor of 7β-hydroxysteroid dehydrogenase type1 (17β-HSD1), exhibiting IC50 values of 43 nM for 17β-HSD1 and 6.2μM for 17β-HSD2. This compound is utilized in research related to metabolic diseases, particularly endometriosis [1].
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Description | Steroid sulfatase/17β-HSD1-IN-5 serves as an irreversible inhibitor of steroid sulfatase (STS) and a reversible, selective inhibitor of 7β-hydroxysteroid dehydrogenase type1 (17β-HSD1), exhibiting IC50 values of 43 nM for 17β-HSD1 and 6.2μM for 17β-HSD2. This compound is utilized in research related to metabolic diseases, particularly endometriosis [1]. |
In vitro | Steroid sulfatase/17β-HSD1-IN-5 (Compound 5) at concentrations up to 31 μM (HEK293) and 23 μM (HepG2) does not affect cell viability when administered in the range of 0-40 μM for 48-72 hours [1]. |
In vivo | Steroid sulfatase/17β-HSD1-IN-5 (Compound 5), when administered as a single subcutaneous injection at a dose of 50 mg/kg, exhibited a half-life (T 1/2) of 3.82 hours and an observed maximum plasma concentration (C max obs) of 2824 nM [1]. |
Molecular Weight | N/A |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Steroid sulfatase/17β-HSD1-IN-5 inhibitor inhibit