Poly diallyldimethylammonium chloride

Poly diallyldimethylammonium chloride is a cationic antimicrobial polymer featuring quaternary ammonium side groups, exhibiting microbicidal properties. It is utilized in studies involving bacterial and fungal infections, including Escherichia coli, Staphylococcus aureus, and Candida albicans infections.

Poly diallyldimethylammonium (chloride) is used in nanoparticle synthesis at concentrations of 3-5 mg/mL, resulting in a final PDDA concentration of 1.53-3.24 mg/mL in formulations A3, A4, A5, B3, B4, and B5. PMMA/PDDA nanoparticles incorporating PDDA demonstrate excellent long-term colloidal stability with a zeta average particle size of 230-328 nm and a zeta potential of 62-69 mV, showing low polydispersity; however, the outer PDDA layer collapses under high ionic strength. Free Poly diallyldimethylammonium (chloride) at concentrations of 0.003-1.5 mg/mL for 1 hour effectively kills Escherichia coli ATCC 25322 and Candida albicans ATCC 90028, with a minimum microbicidal concentration (MMC) of 0.005 mg/mL, but shows weak activity against Staphylococcus aureus ATCC 29213 (MMC > 0.5 mg/mL). Compared to free PDDA, PMMA/PDDA nanoparticles exhibit reduced antibacterial activity against S. aureus and C. albicans and increased hemolytic toxicity. While free PDDA at bactericidal concentrations does not induce hemolysis, PMMA/PDDA nanoparticles cause significant hemolysis at concentrations effective against S. aureus ATCC 29213 and C. albicans ATCC 90028.