keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Certain chronic neurologic disorders, such as Parkinson's disease, are caused by an insufficiency of the neurotransmitter dopamine secondary to the degeneration of substantia nigra dopaminergic neurons. N-(α-Linolenoyl) tyrosine (NALT) is a simple α-amide conjugate between the ω-3 essential fatty acid α-linolenate and the amino acid tyrosine. α-Linolenate is an important precursor to docosahexaenoic acid (DHA), a prominent brain polyunsaturated fatty acid, while tyrosine is the metabolic precursor for neuronal dopamine synthesis. NALT was prepared as a method for enhancing central nervous system (CNS) dopamine content by facilitated transport of the tyrosine precursor across the blood-brain barrier. In experimental rat models of dopamine insufficiency, NALT increased CNS dopamine levels and exhibited an activity profile consistent with an anti-Parkinson's therapeutic agent.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | 35 days | $ 178.00 | |
10 mg | 35 days | $ 333.00 | |
50 mg | 35 days | $ 1,380.00 | |
100 mg | 35 days | $ 2,420.00 |
Description | Certain chronic neurologic disorders, such as Parkinson's disease, are caused by an insufficiency of the neurotransmitter dopamine secondary to the degeneration of substantia nigra dopaminergic neurons. N-(α-Linolenoyl) tyrosine (NALT) is a simple α-amide conjugate between the ω-3 essential fatty acid α-linolenate and the amino acid tyrosine. α-Linolenate is an important precursor to docosahexaenoic acid (DHA), a prominent brain polyunsaturated fatty acid, while tyrosine is the metabolic precursor for neuronal dopamine synthesis. NALT was prepared as a method for enhancing central nervous system (CNS) dopamine content by facilitated transport of the tyrosine precursor across the blood-brain barrier. In experimental rat models of dopamine insufficiency, NALT increased CNS dopamine levels and exhibited an activity profile consistent with an anti-Parkinson's therapeutic agent. |
Molecular Weight | 441.6 |
Formula | C27H39NO4 |
CAS No. | 259143-19-6 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMF: 30 mg/mL
PBS (pH 7.2): 1 mg/mL
Ethanol: 30 mg/mL
DMSO: 30 mg/mL
You can also refer to dose conversion for different animals. More
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N-(α-Linolenoyl) Tyrosine 259143-19-6 N (α Linolenoyl) Tyrosine N(αLinolenoyl) Tyrosine N-(a-Linolenoyl) Tyrosine N-(alpha-Linolenoyl) Tyrosine inhibitor inhibit