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N′-(2-Chloroethyl)-N-(4-methylcyclohexyl)-N-nitrosourea

Name: N′-(2-Chloroethyl)-N-(4-methylcyclohexyl)-N-nitrosourea
Brand: TargetMol
SKU: T73592
Rating: 4.5 (1 reviews)

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Catalog No. T73592Cas No. 75219-93-1

N′-(2-Chloroethyl)-N-(4-methylcyclohexyl)-N-nitrosourea has antitumor activity and is used in the treatment of Lewis lung and colon tumors.

N′-(2-Chloroethyl)-N-(4-methylcyclohexyl)-N-nitrosourea

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Catalog No. T73592Cas No. 75219-93-1

N′-(2-Chloroethyl)-N-(4-methylcyclohexyl)-N-nitrosourea has antitumor activity and is used in the treatment of Lewis lung and colon tumors.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$82	Inquiry	Inquiry
5 mg	$181	Inquiry	Inquiry
10 mg	$267	Inquiry	Inquiry
25 mg	$413	Inquiry	Inquiry
50 mg	$592	Inquiry	Inquiry
100 mg	$819	Inquiry	Inquiry
200 mg	$1,090	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

N′-(2-Chloroethyl)-N-(4-methylcyclohexyl)-N-nitrosourea AI Summary

N′-(2-Chloroethyl)-N-(4-methylcyclohexyl)-N-nitrosourea exhibits bioactivity as an inhibitor of soluble epoxide hydrolase (sEH). It demonstrates inhibition of sEH from an unspecified origin using PHOME as a substrate, leading to the formation of 6-methoxy-2-naphthaldehyde. The compound has an IC50 value of 20200.0 nM, shows an inhibition of 86.9% at a 100 μM concentration, and displays mixed-type inhibition with a Ki value of 2000.0 nM during experimental assessments. These results suggest that N′-(2-Chloroethyl)-N-(4-methylcyclohexyl)-N-nitrosourea has potential as an sEH inhibitor..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

N′-(2-Chloroethyl)-N-(4-methylcyclohexyl)-N-nitrosourea has antitumor activity and is used in the treatment of Lewis lung and colon tumors.

Chemical Properties

Molecular Weight	247.72
Formula	C₁₀H₁₈ClN₃O₂
Cas No.	75219-93-1
Smiles	CC1CCC(N(N=O)C(NCCCl)=O)CC1
Relative Density.	1.31 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (201.84 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0368 mL	20.1841 mL	40.3682 mL	201.8408 mL
5 mM	0.8074 mL	4.0368 mL	8.0736 mL	40.3682 mL
10 mM	0.4037 mL	2.0184 mL	4.0368 mL	20.1841 mL
20 mM	0.2018 mL	1.0092 mL	2.0184 mL	10.0920 mL
50 mM	0.0807 mL	0.4037 mL	0.8074 mL	4.0368 mL
100 mM	0.0404 mL	0.2018 mL	0.4037 mL	2.0184 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

N′(2Chloroethyl)N(4methylcyclohexyl)Nnitrosourea

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