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CLK1/4-IN-2
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Catalog No. T219060 Copy Product Info
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CLK1/4-IN-2 is a selective inhibitor of CLK1/4 with an IC50 of 7 nM for CLK1 and 2.3 nM for CLK4. It induces protein depletion in cancer cells and exhibits anticancer activity. CLK1/4-IN-2 is applicable in research related to breast cancer, monocytic leukemia, bladder cancer, mammary adenocarcinoma, and hepatocellular carcinoma.
CLK1/4-IN-2
Cas No. 2101206-26-0
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | CLK1/4-IN-2 is a selective inhibitor of CLK1/4 with an IC50 of 7 nM for CLK1 and 2.3 nM for CLK4. It induces protein depletion in cancer cells and exhibits anticancer activity. CLK1/4-IN-2 is applicable in research related to breast cancer, monocytic leukemia, bladder cancer, mammary adenocarcinoma, and hepatocellular carcinoma. |
| Targets & IC50 | CLK1:7 nM |
| In vitro | CLK1/4-IN-2 effectively inhibits the proliferation of human cancer cell lines within 2-5 days while demonstrating low cytotoxicity toward non-tumorigenic peripheral blood lymphocytes and HEK293 cells. In concentrations ranging from 1.25-20 μM over 3 days, it reduces levels of cancer-related proteins [EGFR and HDAC1 in T24 cells; EGFR and p70S6 kinase in MDA-MB-231 cells; HDAC1 and p70S6 kinase in HepG2 cells], correlating with the sensitivity of cell lines to proliferation inhibition. |
| Molecular Weight | 329.39 |
| Formula | C18H16FNO2S |
| Cas No. | 2101206-26-0 |
| Smiles | O=C(C=1SC=2C=CC(OC)=CC2C1)N(C)CC=3C=CC=C(F)C3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: CLK1/4-IN-2 in vitro | CLK1/4-IN-2 formula | CLK1/4-IN-2 molecular weight
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