Bromochloro-5,5-dimethylhydantoin

Bromochloro-5,5-dimethylhydantoin is a biocide and membrane disruptor. It damages bacterial cell membranes, alters their structure and permeability, and induces leakage of soluble proteins and ions within bacterial cells. Bromochloro-5,5-dimethylhydantoin exhibits bactericidal activity.

Bromochloro-5,5-dimethylhydantoin exhibits potent bactericidal activity against Escherichia coli 8099 at concentrations of 5-25 mg/L over a 3-minute exposure. Concentrations of 20 mg/L and 25 mg/L result in a significant reduction in viable bacteria, with decreases of 6.56 and 6.99 log 10, respectively, after 3 minutes. Lower concentrations produce minimal or no bactericidal effects. Additionally, at 20 mg/L, this compound induces cell elongation in E. coli 8099, indicating an SOS response, with visibly less membrane damage compared to other treatments. Furthermore, at 20 mg/L, limited leakage of potassium and magnesium ions occurs within 1 to 20 minutes post-exposure, with ion levels remaining near baseline throughout the 20-minute duration.