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Anti-COREST Antibody (5R620)
😃Good
Catalog No. TMAB-04586
Anti-COREST Antibody (5R620) is a Rabbit antibody targeting COREST. Anti-COREST Antibody (5R620) can be used in IHC-P,IHC-Fr,ICC/IF,IF,FCM.
Anti-COREST Antibody (5R620)
Anti-COREST Antibody (5R620)
😃Good
Catalog No. TMAB-04586
Anti-COREST Antibody (5R620) is a Rabbit antibody targeting COREST. Anti-COREST Antibody (5R620) can be used in IHC-P,IHC-Fr,ICC/IF,IF,FCM.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 μL | $148 | 7-10 days | 7-10 days | |
| 50 μL | $262 | 7-10 days | 7-10 days | |
| 100 μL | $473 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-COREST Antibody (5R620) is a Rabbit antibody targeting COREST. Anti-COREST Antibody (5R620) can be used in IHC-P,IHC-Fr,ICC/IF,IF,FCM. |
| Ig Type | IgG |
| Clone | 5R620 |
| Reactivity | Human (predicted:Mouse,Rat) |
| Application | |
| Recommended Dose | IHC-P: 1:50-200; IHC-Fr: 1:50-200; ICC/IF: 1:50-200; IF: 1:50-200; FCM: 1:50-100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. Upon infection by HSV-1, it is partially translocated into the cytoplasm in an HSV-1-dependent manner. |
| Tissue Specificity | Ubiquitously expressed. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| Research Background | Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. |
| Immunogen | A synthesized peptide: human REST corepressor 1 |
| Antigen Species | Human |
| Gene Name | RCOR1 |
| Gene ID | |
| Protein Name | REST corepressor 1 |
| Uniprot ID | |
| Function | Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. |
| Molecular Weight | Theoretical: 53 kDa. Actual: 66 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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