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UNIL-088

Catalog No. T34999 CAS 473545-11-8

Synonyms: UNIL 088

UNIL088 is a water-soluble prodrug of cyclosporine A (CsA) designed for topical ocular delivery. The pro-moiety is grafted via an ester function to CsA and the solubilizing group is a phosphate ion. UNIL-088 can be rapidly hydrolysed under physiological conditions, and can retain a long shelf-life in aqueous media. UNIL-088 is more stable at pH 5 than at pH 7 with conversion rate constant of 3.2 x 10(-3) and 26.0 x 10(-3)days(-1), respectively.

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UNIL-088, CAS 473545-11-8

Pack Size	Availability	Price/USD	Quantity
25 mg	Inquiry	$ 1,520.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	UNIL 088
Molecular Weight	1570.87
Formula	C73H128N13O22P
CAS No.	473545-11-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Lallemand, F.; Varesio, E.; Felt-Baeyens, O.; Bossy, Leila; Hopfgartner, G.; Gurny, R. Biological conversion of a water-soluble prodrug of cyclosporine A. European Journal of Pharmaceutics and Biopharmaceutics (2007), 67(2), 555-561. 2. Lallemand, F.; Behar-Cohen, F.; Felt-Baeyens, O.; Rudaz, S.; Furrer, P.; Besseghir, K.; Dumont, J.-M.; Gurny, R. Cyclosporine A prodrug for topical delivery to the eye. Ocular Pharmacology and Therapeutics--ISOPT, Proceedings of the International Symposium, 5th, Monte Carlo, Monaco, Mar. 11-14, 2004 (2004), 105-109. 3. Lallemand, Frederic; Perottet, Philippe; Felt-Baeyens, Olivia; Kloeti, Werner; Philippoz, Florence; Marfurt, Judith; Besseghir, Kamel; Gurny, RobertA water-soluble prodrug of cyclosporine A for ocular application: A stability study. European Journal of Pharmaceutical Sciences (2005), 26(1), 124-129. 4. Lallemand, F.; Furrer, P.; Felt-Baeyens, O.; Gex-Fabry, M.; Dumont, J.-M.; Besseghir, K.; Gurny, R. A novel water-soluble cyclosporine A prodrug: ocular tolerance and in vivo kinetics. International Journal of Pharmaceutics (2005), 295(1-2), 7-14.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

UNIL-088 473545-11-8 UNIL088 UNIL 088 inhibitor inhibit

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