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Tosylchloramide sodium trihydrate

Catalog No. T19587 CAS 7080-50-4

Tosylchloramide sodium trihydrate is an agent of disinfectant. It is also used as a biocide in air fresheners and deodorants.

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Tosylchloramide sodium trihydrate Chemical Structure

Tosylchloramide sodium trihydrate, CAS 7080-50-4

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Biological Description

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Description	Tosylchloramide sodium trihydrate is an agent of disinfectant. It is also used as a biocide in air fresheners and deodorants.
In vitro	Tosylchloramide effectively suppresses both Gram-positive bacterial growth and E. coli (gram-negative; with/without serum) proliferation. Gram-positive bacteria are diminished by 95-100% across all dosages and in the presence or absence of serum. For E. coli, reductions of 94-100% occur at antiseptic levels of 300 and 400 ppm. At a lower concentration of 200 ppm, E. coli growth is completely halted without serum and reduced by 50% when serum is present. Moreover, at concentrations of 100 and 200 ppm, cell viability exceeds 90% regardless of the experimental conditions. A brief, 3-minute exposure to a 300-ppm concentration of tosylchloramide maintains up to 70% cell viability, although extended exposure further diminishes viability. Notably, serum exposure does not influence cell viability under any tested conditions[1].
In vivo	In rat tissues, significant dose-dependent DNA damage and inflammation were observed histopathologically around the terminal airways of the lung in both sexes after exposure to tosylchloramide. Additionally, a 24-hour exposure to 50 mg/L of chloramine-T was found toxic to crayfish, causing a significant energy loss evident during subsequent physical stress tests. Tosylchloramide has been noted to potentially enhance the toxicity of various xenobiotics through metabolic activation and/or the accumulation of reactive metabolites. Specifically, the activities of enzymes CYP2E1, CYP1A1/2, CYP2B1/2, CYP3A4, and CYP4A1/2 significantly increased in a dose-dependent manner with tosylchloramide doses of 2.50, 5, and 10 mg/kg bw/day. This increase in enzyme activity was not observed at a lower dose of 1.25 mg/kg bw/day.

Molecular Weight	246.66
Formula	C7H10ClNNaO3S
CAS No.	7080-50-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Kloth LC, et al. Bactericidal and cytotoxic effects of chloramine-T on wound pathogens and human fibroblasts in vitro. Adv Skin Wound Care. 2007 Jun;20(6):331-45. 2. Shim I, et al. Inhalation exposure to chloramine T induces DNA damage and inflammation in lung of Sprague-Dawley rats. J Toxicol Sci. 2013;38(6):937-46. 3. Kuklina I, et al. Investigation of chloramine-T impact on crayfish Astacus leptodactylus (Esch., 1823) cardiac activity. Environ Sci Pollut Res Int. 2014 Sep;21(17):10262-9. 4. Martínez MA, et al. Induction of cytochrome P450-dependent mixed function oxidase activities and peroxisome proliferation by chloramine-T in male rat liver. Food Chem Toxicol. 2017 Aug;106(Pt A):86-91.

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