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Tedizolid HCl (856866-72-3 free base)

Catalog No. T23451 CAS T23451

Synonyms: Tedizolid HCl

Tedizolid HCl is a reversible, novel oxazolidinone antibiotic (IC50: for MAO-A (monoamine oxidase-A), 8.7 uM; for MAO-B, 5.7 uM). It is the first oxazolidinone to be approved since linezolid in 2000. Tedizolid phosphate is the second commercially available oxazolidinone antibiotic and is the prodrug form of tedizolid with a fixed once-daily dose. As an expanded-spectrum oxazolidinone, it has potent activity against a wide range of Gram-positive pathogens.

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Tedizolid HCl (856866-72-3 free base) Chemical Structure

Tedizolid HCl (856866-72-3 free base), CAS T23451

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5 mg	Inquiry	$ 115.00
10 mg	Inquiry	$ 171.00
50 mg	Inquiry	$ 487.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Tedizolid HCl is a reversible, novel oxazolidinone antibiotic (IC50: for MAO-A (monoamine oxidase-A), 8.7 uM; for MAO-B, 5.7 uM). It is the first oxazolidinone to be approved since linezolid in 2000. Tedizolid phosphate is the second commercially available oxazolidinone antibiotic and is the prodrug form of tedizolid with a fixed once-daily dose. As an expanded-spectrum oxazolidinone, it has potent activity against a wide range of Gram-positive pathogens.
In vitro	In vitro, tedizolid was a reversible inhibitor for both human MAO-A and MAO-B; for MAO-A, the value of IC50 was 8.7 uM, and for MAO-B, the value of IC50 was 5.7 uM. For these two inhibitions, add 46.0 and 2.1 uM of linezolid, respectively would be better [2].
In vivo	In vivo: It exhibited not only a potent activity against Gram-positive pathogens but also maintained activity against linezolid resistant bacteria. In the murine serotonergic model, the number of head twitches was analyzed after tedizolid phosphate was administrated by intraperitoneal injection [2].

Synonyms	Tedizolid HCl
Molecular Weight	406.8
Formula	C17H16ClFN6O3
CAS No.	T23451

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: > 13.57 mg/mL, Heating is recommended.

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You can also refer to dose conversion for different animals. More

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

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