Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tankyrase-IN-2 is a selective, potent and orally active inhibitor of tankyrase with IC50s of 10, 7, and 710 nM for TNKS1, TNKS2 as well as PARP1, respectively
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,400.00 | |
50 mg | 6-8 weeks | $ 1,820.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | Tankyrase-IN-2 is a selective, potent and orally active inhibitor of tankyrase with IC50s of 10, 7, and 710 nM for TNKS1, TNKS2 as well as PARP1, respectively |
Targets&IC50 | TNKS1:10 nM , PARP1:710 nM , TNKS2:7 nM |
In vitro | In DLD1 cells, Tankyrase-IN-2 (1-10000 nM; 24 hours) leads to a dose-dependent increase of tankyrase protein abundance (EC50 of 320 nM). This is in the same potency range as the value for axin2 increase with EC50 of 319 nM. |
Molecular Weight | 316.3 |
Formula | C17H14F2N2O2 |
CAS No. | 1588870-36-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Tankyrase-IN-2 1588870-36-3 Cytoskeletal Signaling Stem Cells Wnt/beta-catenin TankyraseIN2 Tankyrase IN 2 inhibitor inhibit