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TAXUSIN

🥰Excellent
Catalog No. TN6763Cas No. 19605-80-2

TAXUSIN is a natural product of the yew tree and has certain anticancer and analgesic activities.

TAXUSIN

TAXUSIN

🥰Excellent
Purity: 99.7%
Catalog No. TN6763Cas No. 19605-80-2
TAXUSIN is a natural product of the yew tree and has certain anticancer and analgesic activities.
Pack SizePriceAvailabilityQuantity
1 mg$500In Stock
5 mg$1,110In Stock
10 mg$1,710In Stock
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Purity:99.7%
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COA HPLC HNMR MS CNMR

Product Introduction

Bioactivity
Description
TAXUSIN is a natural product of the yew tree and has certain anticancer and analgesic activities.
Targets&IC50
NO:22.1 μM
In vitro
METHODS: Taxusin and verapamil (0.1/1/10μg/mL) were used to determine the accumulation of vincristine (VCR) in multi-drug-resistant human ovarian cancer 2780AD cells.
RESULTS Taxusin's activity against VCR accumulation in multidrug-resistant tumor cells was approximately 1.5 times that of microverapamil. [1]
In vivo
METHODS: Taxusin was administered to mice at 30 mg/kg by intraperitoneal injection to treat the painful effect of abdominal contraction caused by p-benzoquinone. RESULTS Taxusin exhibited significant analgesic effects on abdominal contractions induced by p-benzoquinone.
Chemical Properties
Molecular Weight504.61
FormulaC28H40O8
Cas No.19605-80-2
SmilesC[C@]12[C@@H](OC(C)=O)[C@H](OC(C)=O)C=3C(C)(C)[C@](C[C@@]1(C(=C)[C@@H](OC(C)=O)CC2)[H])(C[C@H](OC(C)=O)C3C)[H]
Relative Density.1.16 g/cm3 (Predicted)
Storage & Solubility Information
Storagekeep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 6.25 mg/mL (12.39 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.9817 mL9.9086 mL19.8173 mL99.0864 mL
5 mM0.3963 mL1.9817 mL3.9635 mL19.8173 mL
10 mM0.1982 mL0.9909 mL1.9817 mL9.9086 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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2 Enter the in vivo formulation:
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Keywords

TAXUSIN
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