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ONO4057

Catalog No. T16395 CAS 134578-96-4

Synonyms: ONO-LB457

ONO4057 is a potent and orally active Leukotriene B4 receptor antagonist with an IC50 value of 0.7±0.3 μM. Immunosuppressive effect of ONO4057 on rat allografts.

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ONO4057, CAS 134578-96-4

Pack Size	Availability	Price/USD	Quantity
1 mg	In stock	$ 700.00
5 mg	In stock	$ 1,800.00

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Purity: 100%

Biological Description

Chemical Properties

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Description	ONO4057 is a potent and orally active Leukotriene B4 receptor antagonist with an IC50 value of 0.7±0.3 μM. Immunosuppressive effect of ONO4057 on rat allografts.
Targets&IC50	LTB4:0.7 μM
In vivo	The mean animal survivals of ONO4057-treated animals significantly prolong to 21.0±4.4 days compared with 12.0±0.6 days in the control group. Histological findings from grafts taken on day 7 show that severe focal cellular infiltration is observed in both groups, but the degree of hepatocyte necrosis in ONO4057-treated animals is milder than that in the control group[1].

Synonyms	ONO-LB457
Molecular Weight	470.55
Formula	C27H34O7
CAS No.	134578-96-4

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Tanaka M, et al. Effect of leukotriene B(4) receptor antagonist (ONO4057) on hepatic allografting in rats. Transplant Proc. 2000 Nov;32(7):2340. 2. Kishikawa K, et al. ONO-4057, a novel, orally active leukotriene B4 antagonist: effects on LTB4-induced neutrophil functions. Prostaglandins. 1992 Oct;44(4):261-75.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library

Related Products

Related compounds with same targets

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Keywords

ONO4057 134578-96-4 GPCR/G Protein Leukotriene Receptor ONO-LB-457 ONO-4057 ONO-LB 457 ONO 4057 ONO-LB457 inhibitor inhibit

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