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NP213

Catalog No. TP2149L CAS 942577-31-3

NP213 is a rapidly acting synthetic antimicrobial peptide (AMP). NP213 is effective and well-tolerated in resolving nail fungal infections. NP213 has anti-fungal activities. NP213 targets the fungal cytoplasmic membrane and plays its role via membrane perturbation and disruption.

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NP213, CAS 942577-31-3

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Purity: 98%

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Description	NP213 is a rapidly acting synthetic antimicrobial peptide (AMP). NP213 is effective and well-tolerated in resolving nail fungal infections. NP213 has anti-fungal activities. NP213 targets the fungal cytoplasmic membrane and plays its role via membrane perturbation and disruption.
In vitro	NP213 is against T. rubrum NCPF0118, which shows different MIC values against T. rubrum NCPF0118, and the MICs vary depending on the source of the keratin. NP213 (2-3 hours; 0-8 μg/ml) has great activity against clinically relevant yeast, including candida spp, Cryptococcus app, and Trichosporon spp. For all 122 yeast isolates, with the median MIC100 values of 1-2 μg/ml. NP213 (500-1000 μg/mL; 18 hours) enhances the number of PI-stained T. rubrum NCPF0118 cells in samples. These results shows that NP213 is fungicidal and the mechanisms of action involved membrane permeabilization. The MIC values are 16-32 mg/L, 125 mg/L, and 250 mg/L for NP213 in 1640 media containing human nail Keratin, human skin Keratin, and Lamb's wool Keratin, respectively[1][3].
In vivo	NP213 is tolerated and efficacious and exhibits a half-life of approximately 4.5 h, in Murine models of acute disseminated candidiasis. NP213 (25 mg/kg) is well tolerated in mice [3].

Molecular Weight	1093.3
Formula	C42H84N28O7
CAS No.	942577-31-3

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

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( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Mercer DK,et al. Improved Methods for Assessing Therapeutic Potential of Antifungal Agents against Dermatophytes and Their Application in the Development of NP213, a Novel Onychomycosis Therapy Candidate.Antimicrob Agents Chemother. 2019 Apr 25;63(5). pii: e02117-18 2. Neelabh, et al. Sequential and Structural Aspects of Antifungal Peptides from Animals, Bacteria and Fungi Based on Bioinformatics Tools.Probiotics Antimicrob Proteins. 2016 Jun;8(2):85-101. 3. Novamycin®/NP339 Technology Summary

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Keywords

NP213 942577-31-3 Chromatin/Epigenetic Epigenetic Reader Domain NP-213 Inhibitor inhibitor inhibit

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