Powder: -20°C for 3 years
In solvent: -80°C for 2 years
NP213 is a rapidly acting synthetic antimicrobial peptide (AMP). NP213 is effective and well-tolerated in resolving nail fungal infections. NP213 has anti-fungal activities. NP213 targets the fungal cytoplasmic membrane and plays its role via membrane perturbation and disruption.
Description | NP213 is a rapidly acting synthetic antimicrobial peptide (AMP). NP213 is effective and well-tolerated in resolving nail fungal infections. NP213 has anti-fungal activities. NP213 targets the fungal cytoplasmic membrane and plays its role via membrane perturbation and disruption. |
In vitro | NP213 is against T. rubrum NCPF0118, which shows different MIC values against T. rubrum NCPF0118, and the MICs vary depending on the source of the keratin. NP213 (2-3 hours; 0-8 μg/ml) has great activity against clinically relevant yeast, including candida spp, Cryptococcus app, and Trichosporon spp. For all 122 yeast isolates, with the median MIC100 values of 1-2 μg/ml. NP213 (500-1000 μg/mL; 18 hours) enhances the number of PI-stained T. rubrum NCPF0118 cells in samples. These results shows that NP213 is fungicidal and the mechanisms of action involved membrane permeabilization. The MIC values are 16-32 mg/L, 125 mg/L, and 250 mg/L for NP213 in 1640 media containing human nail Keratin, human skin Keratin, and Lamb's wool Keratin, respectively[1][3]. |
In vivo | NP213 is tolerated and efficacious and exhibits a half-life of approximately 4.5 h, in Murine models of acute disseminated candidiasis. NP213 (25 mg/kg) is well tolerated in mice [3]. |
Molecular Weight | 1093.3 |
Formula | C42H84N28O7 |
CAS No. | 942577-31-3 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
( < 1 mg/ml refers to the product slightly soluble or insoluble )
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NP213 942577-31-3 Chromatin/Epigenetic Epigenetic Reader Domain NP-213 Inhibitor inhibitor inhibit