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LAI-1

Catalog No. T32537 CAS 1046789-93-8

Synonyms: LAI 1, Legionella autoinducer-1, Legionella autoinducer 1

LAI-1 is a regulator of bacterial signaling, modulating gene regulation and cellular responses of eukaryotic cells (amoebae or macrophages) and a variety of processes including pathogen-host cell interactions.

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LAI-1, CAS 1046789-93-8

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

Bulk Inquiry

This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	LAI 1, Legionella autoinducer-1, Legionella autoinducer 1
Molecular Weight	242.4
Formula	C15H30O2
CAS No.	1046789-93-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Guedes IA, Freitas RH, Cordeiro NM, do Nascimento TS, Valerio TS, Fernandes PD, Dardenne LE, Fraga CA. LASSBio-1829 Hydrochloride: Development of a New Orally Active N-Acylhydrazone IKK2 Inhibitor with Anti-inflammatory Properties. ChemMedChem. 2016 Jan 19;11(2):234-44. doi: 10.1002/cmdc.201500266. Epub 2015 Aug 25. PubMed PMID: 26306006. 1: Personnic N, Striednig B, Hilbi H. Legionella quorum sensing and its role in pathogen-host interactions. Curr Opin Microbiol. 2018 Feb;41:29-35. doi: 10.1016/j.mib.2017.11.010. Epub 2017 Nov 27. Review. PubMed PMID: 29190490. 2. Hochstrasser R, Hilbi H. Intra-Species and Inter-Kingdom Signaling of Legionella pneumophila. Front Microbiol. 2017 Feb 3;8:79. doi: 10.3389/fmicb.2017.00079. eCollection 2017. Review. PubMed PMID: 28217110; PubMed Central PMCID: PMC5289986. 3. Schell U, Simon S, Hilbi H. Inflammasome Recognition and Regulation of the Legionella Flagellum. Curr Top Microbiol Immunol. 2016;397:161-81. doi: 10.1007/978-3-319-41171-2_8. Review. PubMed PMID: 27460809. 4. Simon S, Schell U, Heuer N, Hager D, Albers MF, Matthias J, Fahrnbauer F, Trauner D, Eichinger L, Hedberg C, Hilbi H. Inter-kingdom Signaling by the Legionella Quorum Sensing Molecule LAI-1 Modulates Cell Migration through an IQGAP1-Cdc42-ARHGEF9-Dependent Pathway. PLoS Pathog. 2015 Dec 3;11(12):e1005307. doi: 10.1371/journal.ppat.1005307. eCollection 2015 Dec. PubMed PMID: 26633832; PubMed Central PMCID: PMC4669118.

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

Step One: Enter information below

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Step Two: Enter the in vivo formulation

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Calculator

Molarity Calculator

Dilution Calculator

Reconstitution Calculation

Molecular Weight Calculator

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Molarity Calculator allows you to calculate the

Mass of a compound required to prepare a solution of known volume and concentration
Volume of solution required to dissolve a compound of known mass to a desired concentration
Concentration of a solution resulting from a known mass of compound in a specific volume

See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

Concentration (Start)

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Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Molecule Formula

Molecular Weight g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

LAI-1 1046789-93-8 LAI 1 Legionella autoinducer-1 LAI1 Legionella autoinducer 1 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.