Powder: -20°C for 3 years | In solvent: -80°C for 1 year
K-Ras ligand-Linker Conjugate 6 is a chemical compound that combines a ligand for K-Ras recruiting moiety and a PROTAC linker. This compound can recruit E3 ligases, including VHL, CRBN, MDM2, and IAP. K-Ras ligand-Linker Conjugate 6 is particularly useful in the synthesis of PROTAC K-Ras Degrader-1, a highly effective K-Ras degrader that achieves ≥70% degradation efficacy in SW1573 cells[1].
Pack Size | Availability | Price/USD | Quantity |
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2 mg | 5 days | $ 124.00 |
Description | K-Ras ligand-Linker Conjugate 6 is a chemical compound that combines a ligand for K-Ras recruiting moiety and a PROTAC linker. This compound can recruit E3 ligases, including VHL, CRBN, MDM2, and IAP. K-Ras ligand-Linker Conjugate 6 is particularly useful in the synthesis of PROTAC K-Ras Degrader-1, a highly effective K-Ras degrader that achieves ≥70% degradation efficacy in SW1573 cells[1]. |
In vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
Molecular Weight | 788.98 |
Formula | C42H60N8O7 |
CAS No. | 2378261-89-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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K-Ras ligand-Linker Conjugate 6 2378261-89-1 Others K Ras ligand Linker Conjugate 6 KRas ligandLinker Conjugate 6 inhibitor inhibit