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Heme arginate

Catalog No. T32054   CAS 100438-92-4
Synonyms: Hemearginat, Heme arginate complex, Normosang

Heme arginine (or heme arginine) is a compound of heme and arginine used to treat acute porphyria by reducing the excessive production of δ-aminolevulinic acid, which causes acute symptoms during the onset of acute porphyria.

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Heme arginate Chemical Structure
Heme arginate, CAS 100438-92-4
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Heme arginine (or heme arginine) is a compound of heme and arginine used to treat acute porphyria by reducing the excessive production of δ-aminolevulinic acid, which causes acute symptoms during the onset of acute porphyria.
Synonyms Hemearginat, Heme arginate complex, Normosang
Molecular Weight 790.703
Formula C40H46FeN8O6
CAS No. 100438-92-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Edmunds MC, Czopek A, Wigmore SJ, Kluth DC. Paradoxical effects of heme arginate on survival of myocutaneous flaps. Am J Physiol Regul Integr Comp Physiol. 2014 Jan 1;306(1):R10-22. doi: 10.1152/ajpregu.00240.2013. Epub 2013 Oct 2. PubMed PMID: 24089372; PubMed Central PMCID: PMC3921308. 2. Choudhary AK, Rennie J, Cairns C, Borthwick G, Hughes J, Morton NM, Kluth D, Conway BR. Administration of heme arginate ameliorates murine type 2 diabetes independently of heme oxygenase activity. PLoS One. 2013 Oct 30;8(10):e78209. doi: 10.1371/journal.pone.0078209. eCollection 2013 Oct 30. PubMed PMID: 24205160; PubMed Central PMCID: PMC3813508. 3. Melenovská P, Kopecká J, Krijt J, Hnízda A, Raková K, Janošík M, Wilcken B, Kožich V. Chaperone therapy for homocystinuria: the rescue of CBS mutations by heme arginate. J Inherit Metab Dis. 2015 Mar;38(2):287-94. doi: 10.1007/s10545-014-9781-9. Epub 2014 Oct 21. PubMed PMID: 25331909. 4. Andreas M, Schmid AI, Doberer D, Schewzow K, Weisshaar S, Heinze G, Bilban M, Moser E, Wolzt M. Heme arginate improves reperfusion patterns after ischemia: a randomized, placebo-controlled trial in healthy male subjects. J Cardiovasc Magn Reson. 2012 Aug 2;14:55. doi: 10.1186/1532-429X-14-55. PubMed PMID: 22857721; PubMed Central PMCID: PMC3438022.

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Keywords

Heme arginate 100438-92-4 Hemearginat Heme arginate complex Normosang inhibitor inhibit

 

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