Powder: -20°C for 3 years | In solvent: -80°C for 1 year
HQ-415 is a class of clinically relevant bioactive metal chelators related to clioquinol. The effective concentration eliciting an EC50 for HQ-415 is 15 μM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | 6-8 weeks | $ 198.00 | |
5 mg | 6-8 weeks | $ 347.00 | |
25 mg | 6-8 weeks | $ 1,140.00 | |
50 mg | 6-8 weeks | $ 1,490.00 | |
100 mg | 6-8 weeks | $ 1,990.00 | |
1 mL * 10 mM (in DMSO) | 6-8 weeks | $ 382.00 |
Description | HQ-415 is a class of clinically relevant bioactive metal chelators related to clioquinol. The effective concentration eliciting an EC50 for HQ-415 is 15 μM. |
In vitro | HQ-415 is active in the TDP-43 model, but CQ was not HQ-161 and HQ-415 is retested in the dose for their ability to rescue TDP-43. HQ-415 strongly synergizes with CQ at multiple concentrations in cells expressing α-syn. CQ fails to synergize with HQ-161 and actually antagonizes HQ-161 rescuing activity, in TDP-43-expressing cells. In contrast, despite the fact that CQ was completely inactive against TDP-43, it strongly synergized with HQ-415, decreasing the EC50 from 16 to 5 μM. Both HQ-161 and HQ-415 rescue TDP-43 toxicity. In cells expressing α-syn, HQ-161, despite being inactive on its own, synergized with HQ-415, reducing the EC50 from 21 to 14 μM. |
Molecular Weight | 415.48 |
Formula | C25H25N3O3 |
CAS No. | 430462-93-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 5.6 mg/mL (13.48 mM), Sonication and heating are recommended.
You can also refer to dose conversion for different animals. More
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HQ-415 430462-93-4 Others HQ415 HQ 415 inhibitor inhibit