Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GNE-4997 is a potent and selective inhibitor of the interleukin-2-inducible T-cell kinase (Ki: 0.09 nM). The correlation between the basicity of solubilizing elements in GNE-4997 and off-target antiproliferative effects decreases cytotoxicity.
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Description | GNE-4997 is a potent and selective inhibitor of the interleukin-2-inducible T-cell kinase (Ki: 0.09 nM). The correlation between the basicity of solubilizing elements in GNE-4997 and off-target antiproliferative effects decreases cytotoxicity. |
Targets&IC50 | ITK:(ki)0.09 nM |
In vitro | GNE-4997 inhibits PLC-γ phosphorylation in Jurkat cells by T-cell receptor stimulation (IC50: 4 nM). |
Molecular Weight | 515.58 |
Formula | C25H27F2N5O3S |
CAS No. | 1705602-02-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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GNE-4997 1705602-02-3 Others GNE 4997 GNE4997 inhibitor inhibit