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Faropenem

Catalog No. T38458 CAS 106560-14-9

Faropenem, a highly efficacious and orally bioavailable beta-lactam antibiotic, exhibits an extensive range of in vitro antimicrobial activity against diverse gram-positive and -negative aerobes and anaerobes. Notably, Faropenem possesses inherent resistance to hydrolysis by virtually all beta-lactamases, including extended-spectrum beta-lactamases and AmpC beta-lactamases. Moreover, Faropenem has been developed as an oral prodrug, namely faropenem medoxomil, for the investigation of respiratory tract infections.

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Faropenem, CAS 106560-14-9

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25 mg	Inquiry	$ 1,520.00

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Biological Description

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Storage & Solubility Information

Description	Faropenem, a highly efficacious and orally bioavailable beta-lactam antibiotic, exhibits an extensive range of in vitro antimicrobial activity against diverse gram-positive and -negative aerobes and anaerobes. Notably, Faropenem possesses inherent resistance to hydrolysis by virtually all beta-lactamases, including extended-spectrum beta-lactamases and AmpC beta-lactamases. Moreover, Faropenem has been developed as an oral prodrug, namely faropenem medoxomil, for the investigation of respiratory tract infections.
In vitro	Faropenem is ineffective against methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus faecium (VRE), Pseudomonas aeruginosa, and Stenotrophomonas maltophilia[1]. However, it effectively inhibits all isolates of B. anthracis, with MIC (Minimum Inhibitory Concentration) values ranging from ≤0.06 to >64 μg/liter and an MIC90 (the concentration at which 90% of isolates are inhibited) of 0.5 μg/ml. This MIC90 value for Faropenem is notably lower than those for other β-lactams, such as Meropenem (4 μg/ml), Amoxicillin-clavulanate (4 μg/ml), and Penicillin (8 μg/ml), demonstrating its superior efficacy against B. anthracis[2].
In vivo	Faropenem, administered intraperitoneally (i.p.) at 24 hours post-challenge in 4-, 6-, and 12-hour intervals at dosages of 10, 20, 40, and 80 mg/kg/day for 14 days, demonstrates significant efficacy against B. anthracis in the murine post-exposure prophylaxis inhalation model[1].

Molecular Weight	285.31
Formula	C12H15NO5S
CAS No.	106560-14-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Kristen N Schurek, et al. Faropenem: review of a new oral penem. Expert Rev Anti Infect Ther. 2007 Apr;5(2):185-98. 2. Stanley C Gill, et al. Pharmacokinetic-pharmacodynamic assessment of faropenem in a lethal murine Bacillus anthracis inhalation postexposure prophylaxis model. Antimicrob Agents Chemother. 2010 May;54(5):1678-83.

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Keywords

Faropenem 106560-14-9 inhibitor inhibit

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