Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Emlenoflast sodium (MCC7840 sodium), a sulfonylurea, is a selective NLRP3 inflammasome inhibitor with an IC50 value of less than 100 nM for NLRP3 inflammasome, and can be used in the study of inflammatory diseases.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | 5 days | Inquiry | |
5 mg | 5 days | $ 970.00 | |
25 mg | 6-8 weeks | Inquiry | |
50 mg | 6-8 weeks | Inquiry | |
100 mg | 6-8 weeks | Inquiry |
Description | Emlenoflast sodium (MCC7840 sodium), a sulfonylurea, is a selective NLRP3 inflammasome inhibitor with an IC50 value of less than 100 nM for NLRP3 inflammasome, and can be used in the study of inflammatory diseases. |
Targets&IC50 | NLRP3 inflammasome:<100 nM |
In vitro | Emlenoflast sodium is an MCC950 analogue that exhibits useful activity in inhibiting NLRP3 inflammasome activation with IC50 <100 nM.[1] |
In vivo |
Emlenoflast sodium (4 mg/kg; i.v.; Male C57BL/6 mice) showed t1/2=3.39 h; AUC0-last=107097 ng•h/mL; CL=0.621 mL /min/kg.[2] Emlenoflast sodium (20 mg/kg; p.o.; Male C57BL/6 mice) exhibits good oral bioavailability (67.2%), Cmax (60467 ng/mL) and half-life (5.02 h) in mice.[2] |
Synonyms | MCC7840 sodium |
Molecular Weight | 411.47 |
Formula | C19H24N4NaO3S |
CAS No. | 2380032-29-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 216.0 mg/mL (526.2 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Emlenoflast sodium 2380032-29-9 Immunology/Inflammation NF-Κb NOD MCC7840 sodium inhibitor inhibit