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Durlobactam sodium salt

Catalog No. T11125   CAS 1467157-21-6
Synonyms: ETX2514 sodium salt

Durlobactam sodium salt (ETX2514 sodium salt) is an inhibitor of β-lactamase with IC50 values of 4 nM, 14 nM, and 190 nM for Class A KPC-2, Class C AmpC, and Class D OXA-24, respectively. Durlobactam sodium salt can be used in studies about drug-resistant Gram-negative bacteria including Acinetobacter baumannii.

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Durlobactam sodium salt Chemical Structure
Durlobactam sodium salt, CAS 1467157-21-6
Pack Size Availability Price/USD Quantity
1 mg In stock $ 390.00
2 mg In stock $ 586.00
5 mg In stock $ 896.00
10 mg In stock $ 1,316.00
25 mg In stock $ 1,974.00
50 mg In stock $ 2,760.00
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Purity: 97.01%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Durlobactam sodium salt (ETX2514 sodium salt) is an inhibitor of β-lactamase with IC50 values of 4 nM, 14 nM, and 190 nM for Class A KPC-2, Class C AmpC, and Class D OXA-24, respectively. Durlobactam sodium salt can be used in studies about drug-resistant Gram-negative bacteria including Acinetobacter baumannii.
Targets&IC50 KPC2 (Class A):4 nM , OXA24 (Class D):190 nM , AmpC (Class C):14 nM
In vitro Durlobactam sodium salt exhibited antibacterial activity against Enterobacteriaceae including E. coli, Klebsiella pneumoniae, Enterobacter cloacae, Stenotrophomonas maltophilia and Citrobacter species. Durlobactam sodium salt was also active against colistin-resistant E. coli isolates bearing the mcr-1 plasmid[1].
In vivo Sulbactam–Durlobactam in thigh and lung murine infection models showed a dose-dependent reduction in MDR A. baumannii bacterial counts[1].
Synonyms ETX2514 sodium salt
Molecular Weight 299.23
Formula C8H10N3NaO6S
CAS No. 1467157-21-6

Storage

store at low temperature,keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 2.5 mg/mL (8.35 mM), Sonification is recommended

TargetMolReferences and Literature

1. Durand-Réville TF, et al. ETX2514 is a broad-spectrum β-lactamase inhibitor for the treatment of drug-resistant Gram-negative bacteria including 2. El-Ghali A, et al. Sulbactam-durlobactam: A novel β-lactam-β-lactamase inhibitor combination targeting carbapenem-resistant Acinetobacter baumannii infections. Pharmacotherapy. 2023 Jun;43(6):502-513.

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Keywords

Durlobactam sodium salt 1467157-21-6 Microbiology/Virology Antibacterial ETX-2514 ETX2514 sodium salt ETX 2514 Durlobactam sodium inhibitor inhibit

 

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