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Cyclo(Tyr-Pro)

Catalog No. TN6678   CAS 5654-84-2

Cyclo(Tyr-Pro) shows antibacterial activity towards several marine bacterial species, it also shows weak antagonistic activity against VEGFR2 -CD. Cyclo(Tyr-Pro) and cyclo(Pro-Val) are toxic to both suspension cells and seedlings of Pinus thunbergii, which may offer some clues to research the mechanism of pine wilt disease caused by pine wood nematode.

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Cyclo(Tyr-Pro) Chemical Structure
Cyclo(Tyr-Pro), CAS 5654-84-2
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Cyclo(Tyr-Pro) shows antibacterial activity towards several marine bacterial species, it also shows weak antagonistic activity against VEGFR2 -CD. Cyclo(Tyr-Pro) and cyclo(Pro-Val) are toxic to both suspension cells and seedlings of Pinus thunbergii, which may offer some clues to research the mechanism of pine wilt disease caused by pine wood nematode.
In vitro Various studies have shown the potentially beneficial biological activities of cyclic dipeptides and in particular, cyclo(L-tyrosyl-L-prolyl) (Cyclo(Tyr-Pro)) has shown fair antibacterial activity in vitro. This study aimed to determine if liposome encapsulation would have any significant effects on the antibacterial activity of this compound. METHODS AND RESULTS:The thin-film hydration method with extrusion was used to produce small unilamellar vesicles containing Cyclo(Tyr-Pro) that were shown to have an average encapsulation of 9.4% with a mean particle size of 160.4 nm. Minimum inhibitory concentrations tested against Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae and Bacillus subtillis were shown to be lower in liposome encapsulated Cyclo(Tyr-Pro) than for the free form, while no antimicrobial activity was noted for either encapsulated nor non-encapsulated drug against the fungus Candida albicans or two methicillin-resistant strains of Staphylococcus aureus (MRSA). A positive control of liposome encapsulated amoxicillin was shown to be extremely active against both MRSA strains. CONCLUSIONS:The results confirm that liposome encapsulation has the potential to enhance activity as well as to overcome bacterial resistance towards current antibacterial agents.
Molecular Weight 260.29
Formula C14H16N2O3
CAS No. 5654-84-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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( < 1 mg/ml refers to the product slightly soluble or insoluble )

TargetMolReferences and Literature

1. Antimicrobial activity of liposome encapsulated cyclo(L-tyrosyl-L-prolyl) Die Pharmazie - An International Journal of Pharmaceutical Sciences,2011,66(6):421-3.

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Keywords

Cyclo(Tyr-Pro) 5654-84-2 Cyclo(Tyr Pro) Cyclo(TyrPro) inhibitor inhibit

 

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