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CDK2 acetate(255064-79-0 free base)

Catalog No. TP1875L CAS TP1875L

CDK2 acetate is a member of the eukaryotic S/T protein kinase family and its function is to catalyze the phosphoryl transfer of ATP γ-phosphate to serine or threonine hydroxyl (denoted as S0/T0) in a protein substrate.

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CDK2 acetate(255064-79-0 free base) Chemical Structure

CDK2 acetate(255064-79-0 free base), CAS TP1875L

Pack Size	Availability	Price/USD
1 mg	In stock	$ 103.00
5 mg	In stock	$ 413.00
10 mg	In stock	$ 613.00
25 mg	In stock	$ 979.00
50 mg	In stock	$ 1,320.00
100 mg	In stock	$ 1,780.00
500 mg	In stock	$ 3,570.00

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Purity: 99.21%

Biological Description

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Description

In vitro

CDK2 (Cyclin-dependent kinase 2) is a member of the eukaryotic S/T protein kinase family and its function is to catalyze the phosphoryl transfer of ATP γ-phosphate to serine or threonine hydroxyl (denoted as S0/T0) in a protein substrate. The fully active CDK2 is in complex with HHASPRK (an optimal peptide substrate), namely interactions of CDK2 with peptide substrate and the dynamics of the G-loop. CDK2 participates in eukaryotic cell cycle regulation at the G1/S boundary. CDK2 deregulation has been proved to occur in tumor cells, evoking a strong interest in artificial and native inhibitors. CDK2 activity is tightly regulated by a complex mechanism, including a positive regulatory subunit binding, and phosphorylations at positive and/or negative regulatory sites[1].

Molecular Weight	891.99
Formula	C37H61N15O11
CAS No.	TP1875L

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Bártová I, The mechanism of inhibition of the cyclin-dependent kinase-2 as revealed by the molecular dynamics study on the complex CDK2 with the peptide substrate HHASPRK. Protein Sci. 2005 Feb;14(2):445-51.

Related compound libraries

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Keywords

CDK2 acetate(255064-79-0 free base) TP1875L Others CDK2 acetate(255064790 free base) CDK-2 acetate(255064-79-0 free base) CDK2 acetate(255064 79 0 free base) inhibitor inhibit

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