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CBP/p300-IN-5

Catalog No. T12346 CAS 1889284-33-6

Synonyms: P300/CBP-IN-5

P300/CBP-IN-5 is a potent inhibitor of p300/CBP histone acetyltransferase (IC50 of 18.8 nM).

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CBP/p300-IN-5, CAS 1889284-33-6

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5 mg	35 days	$ 915.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	P300/CBP-IN-5 is a potent inhibitor of p300/CBP histone acetyltransferase (IC50 of 18.8 nM).
Targets&IC50	p300/CBP:18.8 nM
In vitro	P300/CBP-IN-5 inhibits H3K27Ac with an IC50 value of 4.6 nM in PC-3 cells,P300/CBP-IN-5 inhibits p300 LnCap-FGC cellls proliferation with an IC50 of 14.8 nM.?[1].
In vivo	Administration of P300/CBP-IN-5 (7.5 mg/kg/day) is initiated at the time of size match.?P300/CBP-IN-5 induces significant tumor growth inhibition in multiple xenograft tumor models (the tumor growth inhibition of 62% in SuDHL-8 xenograft tumor model;?48% in 22RV1 xenograft tumor model)[1].

Synonyms	P300/CBP-IN-5
Molecular Weight	618.55
Formula	C29H27F5N6O4
CAS No.	1889284-33-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Michael Michaelides, et al. Spirocyclic hat inhibitors and methods for their use. WO2016044770A1.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

CBP/p300-IN-5 1889284-33-6 Chromatin/Epigenetic Epigenetic Reader Domain CBP/p300IN5 CBP/p300 IN 5 CBP/p-300-IN-5 P300/CBP-IN-5 inhibitor inhibit

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