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BI 689648

Catalog No. T14664 CAS 1633009-87-6

BI 689648 is a highly selective inhibitor of aldosterone synthase(CYP11B1 and CYP11B2 with IC50s of 310 and 2.1 nM, respectively).

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BI 689648, CAS 1633009-87-6

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 985.00
50 mg	6-8 weeks	$ 1,280.00
100 mg	6-8 weeks	$ 1,940.00
1 mL * 10 mM (in DMSO)	6-8 weeks	$ 272.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description	BI 689648 is a highly selective inhibitor of aldosterone synthase(CYP11B1 and CYP11B2 with IC50s of 310 and 2.1 nM, respectively).
Targets&IC50	CYP11B2:2.1 nM, CYP11B1:310 nM
In vitro	In comparison with FADs and LCI699, BI 689648 exhibits remarkable selectivity in vitro, demonstrating an IC50 value of 2.1 nM for CYP11B2 and a selectivity factor of 149 over CYP11B1. Meanwhile, FAD286 presents a comparable IC50 value for CYP11B2 at 2.5 nM, but its higher efficacy against CYP11B1 (94 nM) yields a relatively lower selectivity factor of 38, which is about fourfold lesser than that of BI 689648[1].
In vivo	After oral administration in cyno monkeys, BI 689648 (5 mg/kg) exhibits a peak plasma concentration of ~500 nM. BI 689648 exhibits minimal impact on 11-DC and only at very high plasma concentrations (~10 μM)[1]. For BI 689648 (aldosterone EC50=2 nM), appreciable changes in 11-DOC are only noted at plasma concentrations >2000 nM or >1000-fold its aldosterone EC50 while FAD286 shows a window of ~100-fold.

Molecular Weight	298.34
Formula	C16H18N4O2
CAS No.	1633009-87-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (100.56 mM), Sonication and heating are recommended.

References and Literature

1. Weldon SM, et al. Selectivity of BI 689648, a Novel, Highly Selective Aldosterone Synthase Inhibitor: Comparison with FAD286 and LCI699 in Nonhuman Primates. J Pharmacol Exp Ther. 2016 Oct;359(1):142-50.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

BI 689648 1633009-87-6 Others BI689648 BI-689648 inhibitor inhibit

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