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Adrenomedullin (AM) (22-52), human acetate

Catalog No. TP1257L

Synonyms: Adrenomedullin (AM) (22-52), human acetate（159899-65-7 Free base）

Adrenomedullin (AM) (22-52), human acetate is an antagonist of calcitonin generelated peptide receptor in the hindlimb vascular bed of the cat and an adrenomedullin receptor.

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Adrenomedullin (AM) (22-52), human acetate Chemical Structure

Adrenomedullin (AM) (22-52), human acetate, CAS N/A

Pack Size	Availability	Price/USD
1 mg	In stock	$ 221.00
5 mg	In stock	$ 869.00
10 mg	In stock	$ 1,297.00
25 mg	In stock	$ 2,347.00

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Purity: 99.42%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Adrenomedullin (AM) (22-52), human acetate is an antagonist of calcitonin generelated peptide receptor in the hindlimb vascular bed of the cat and an adrenomedullin receptor.

In vitro

Adrenomedullin (AM) (22-52), human acetate（159899-65-7 Free base） competitively inhibits the binding of the Adrenomedullin dose-dependently and inhibits Adrenomedullin -induced cAMP accumulation in rat vascular smooth muscle cells. Adrenomedullin (AM) (22-52), human acetate（159899-65-7 Free base） (30 nmol) selectively and reversibly decreases vasodilator responses to human calcitonin generelated peptide (hCGRP) with similar effect to that of CGRP antagonist[1].

Synonyms	Adrenomedullin (AM) (22-52), human acetate（159899-65-7 Free base）
Molecular Weight	3636.09
Formula	C161H256N46O50

Storage

store at low temperature,keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Ziolkowska A, et al. Effects of adrenomedullin and its fragment 22-52 on basal and ACTH-stimulated secretion of cultured rat adrenocortical cells. Int J Mol Med. 2003 May;11(5):613-5. 2. Champion HC, et al. Adrenomedullin-(22-52) antagonizes vasodilator responses to CGRP but not adrenomedullin in the cat. Am J Physiol. 1997 Jan;272(1 Pt 2):R234-42.

Related compound libraries

This product is contained In the following compound libraries：

Peptide Compound Library

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Rimegepant ML230 α-CGRP (mouse, rat) TFA Vazegepant hydrochloride CGRP antagonist 1 Erenumab β-CGRP, human acetate Galcanezumab

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Keywords

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