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7-Methotrexate

Catalog No. T29486 CAS 52980-66-2

Synonyms: 7-Mtx

7-Methotrexate is used as a chemotherapy agent and immune system suppressant. It is used to treat cancer, autoimmune diseases, ectopic pregnancy, and medical abortions.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

7-Methotrexate, CAS 52980-66-2

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,670.00
50 mg	6-8 weeks	$ 2,180.00
100 mg	6-8 weeks	$ 2,800.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

7-Methotrexate is used as a chemotherapy agent and immune system suppressant. It is used to treat cancer, autoimmune diseases, ectopic pregnancy, and medical abortions.

Synonyms	7-Mtx
Molecular Weight	454.44
Formula	C20H22N8O5
CAS No.	52980-66-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Hung YM, Lin L, Wang YH, Wei JC, Wang PY, Chiou JY. Combination Effect of Anti-Rheumatic Medications for Coronary Artery Diseases Risk in Rheumatoid Arthritis : A Nationwide Population-Based Cohort Study. Curr Med Res Opin. 2018 Jun 25:1-16. doi: 10.1080/03007995.2018.1492910. [Epub ahead of print] PubMed PMID: 29939099. 2. Kesler S, Ogg R, Reddick W, Phillips N, Scoggins M, Glass J, Cheung Y, Pui CH, Robison L, Hudson M, Krull K. Brain network connectivity and executive function in long-term survivors of childhood acute lymphoblastic leukemia. Brain Connect. 2018 Jun 25. doi: 10.1089/brain.2017.0574. [Epub ahead of print] PubMed PMID: 29936880. 3. Sakagami H, Hara Y, Shi H, Iwama S, Nakagawa M, Suzuki H, Tanaka K, Abe T, Tamura N, Takeshima H, Horie N, Kaneko T, Shiratsuchi H, Kaneko T. Change in Anticancer Drug Sensitivity During Neuronal Differentiation of PC12 Cells. In Vivo. 2018 Jul-Aug;32(4):765-770. doi: 10.21873/invivo.11306. PubMed PMID: 29936457. 4. Bitoun S, Nocturne G, Ly B, Krzysiek R, Roques P, Pruvost A, Paoletti A, Pascaud J, Dönnes P, Florence K, Gleizes A, Hincelin-Mery A, Allez M, Hacein-Bey-Abina S, Mackay F, Pallardy M, Le Grand R, Mariette X. Methotrexate and BAFF interaction prevents immunization against TNF inhibitors. Ann Rheum Dis. 2018 Jun 23. pii: annrheumdis-2018-213403. doi: 10.1136/annrheumdis-2018-213403. [Epub ahead of print] PubMed PMID: 29936438.

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Molecular Weight Calculator

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Mass of a compound required to prepare a solution of known volume and concentration
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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
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The answer of 19.713 mg appears in the Mass box

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Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Molecule Formula

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Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

7-Methotrexate 52980-66-2 7 Methotrexate 7Methotrexate 7-Mtx inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.