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4′-Bromoflavone

Catalog No. T39443 CAS 20525-20-6

4′-Bromoflavone is a highly effective inducer of phase II detoxification enzymes and has been identified as a potent agent in cancer chemoprevention.

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4′-Bromoflavone, CAS 20525-20-6

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25 mg	Inquiry	$ 1,520.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	4′-Bromoflavone is a highly effective inducer of phase II detoxification enzymes and has been identified as a potent agent in cancer chemoprevention.
In vitro	4′-Bromoflavone significantly increases quinone reductase (QR) activity in murine hepatoma 1c1c7 cells at low concentrations (10 nM required for doubling activity) and enhances the α- and mu-isoforms of glutathione S-transferase in H4IIE rat hepatoma cells, without toxicity[1]. Additionally, it serves as a strong inhibitor of cytochrome P4501A1-mediated ethoxyresorufin-O-deethylase activity, exhibiting an inhibition concentration (IC50) of 0.86 μM. Importantly, in HepG2 or MCF-7 cells, 4′-Bromoflavone notably reduces the binding of activated benzo[a]pyrene to DNA[1], indicating its potential protective role against certain chemical-induced damages.
In vivo	In short-term dietary studies, 4′-Bromoflavone is also shown to increase QR activity and glutathione levels in rat liver, mammary gland, colon, stomach, and lung in a dose-dependent manner. In studies conducted with female Sprague Dawley rats ,4′-Bromoflavone significantly increases QR activity (phase II enzyme)[1]. In DMBA-treated female Sprague Dawley rats. Dietary administration of 4′-Bromoflavone (2000 and 4000 mg/kg of diet, from 1 week before to 1 week after DMBA) significantly inhibits the incidence and multiplicity of mammary tumors and greatly increases tumor latency[1].

Molecular Weight	301.14
Formula	C15H9BrO2
CAS No.	20525-20-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. L L Song, et al. Cancer chemopreventive activity mediated by 4'-bromoflavone, a potent inducer of phase II detoxification enzymes. Cancer Res. 1999 Feb 1;59(3):578-85.

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Keywords

4′-Bromoflavone 20525-20-6 4′Bromoflavone 4′ Bromoflavone inhibitor inhibit

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