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Product Introduction

Bioactivity

Description	HP-β-CD (HP-β-CD) is a widely used drug delivery vehicle to improve stability and bioavailability.
Targets&IC50	SKOV-3 cells:1.94 μM, leukemia cell:3.86–10.09 mM
In vitro	Cell treatment with (2-hydroxypropyl)-β-cyclodextrin can activate the activation of the transcription factor EB (the main regulator of lysosomal function and autophagy) and enhance the cell's autophagy clearance ability[1]. HP-β-CD treatment reduces intracellular cholesterol resulting in significant leukemic cell growth inhibition through G2/M cell-cycle arrest and apoptosis. The IC50 values for HP-β-CD after 72 hours exposure are in the range of 3.86–10.09 mM. HP-β-CD also shows anticancer effects against CML cells expressing a T315I BCR-ABL mutation (that confers resistance to most ABL tyrosine kinase inhibitors), and hypoxia-adapted CML cells that have characteristics of leukemic stem cells. In addition, colony forming ability of human primary AML and CML cells is inhibited by HP-β-CD[2].
In vivo	Intraperitoneal injection of HP-β-CD significantly improves survival in leukemia mouse models. Systemic administration of HP-β-CD to mice has no significant adverse effects[2].
Alias	Hydroxypropyl-β-cyclodextrin, Hydroxypropyl betadex

Chemical Properties

Cas No.	128446-35-5
Relative Density.	1.05 g/cm3 at 20.3℃

Storage & Solubility Information

Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO: 45.00 mg/mL, Sonication is recommended. H2O: 50.00 mg/mL, Sonication is recommended.

Sci Citations

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

InhibitorinhibitHydroxypropyl-beta-cyclodextrinHydroxypropyl-b-cyclodextrinHP-beta-CDHP-b-CD(2Hydroxypropyl)βcyclodextrin(2 Hydroxypropyl) β cyclodextrin