store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
(1R,2R)-2-PCCA hydrochloride is a potent, selective, and blood-brain-barrier-crossing GPR88 receptor agonist with an EC50 value of 1140 n in striatal membranes of WT mice.(1R,2R)-2-PCCA hydrochloride can be used to study the central nervous system.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 119.00 | |
5 mg | In stock | $ 198.00 | |
10 mg | In stock | $ 372.00 | |
25 mg | In stock | $ 747.00 | |
50 mg | In stock | $ 1,160.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 239.00 |
Description | (1R,2R)-2-PCCA hydrochloride is a potent, selective, and blood-brain-barrier-crossing GPR88 receptor agonist with an EC50 value of 1140 n in striatal membranes of WT mice.(1R,2R)-2-PCCA hydrochloride can be used to study the central nervous system. |
Targets&IC50 | GPR88-22F cells:603 nM (EC50), GPR88 receptor:3 nM (EC50, cell-free assay), GPR88 receptor:56 nM (EC50, HEK293 cell) |
In vitro | (1R,2R)-2-PCCA hydrochloride (Example 3) is an effective GPR88 receptor agonist with an EC50 of 3 nM in cell-free assay experiments and 603 nM in cellular assays[1]. Through the Gαi-coupled pathway, (1R,2R)-2-PCCA hydrochloride inhibits GPR88-mediated cAMP production, with an EC50 of 56 nM cAMP constructs in HEK293 cells stably expressing human GPR88 receptor and GloSensor-22F[1]. |
Synonyms | (1R,2R)-2-PCCA(hydrochloride) |
Molecular Weight | 528.56 |
Formula | C30H39Cl2N3O |
CAS No. | 1609563-71-4 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 20 mg/mL (37.84 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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(1R,2R)-2-PCCA hydrochloride 1609563-71-4 Others (1R,2R)2PCCA hydrochloride 2-PCCA(hydrochloride) (1R,2R)-2-PCCA(hydrochloride) 2-PCCA Hydrochloride (1R,2R) 2 PCCA hydrochloride inhibitor inhibit