Powder: -20°C for 3 years | In solvent: -80°C for 1 year
(±)17-HDHA is an autoxidation product of docosahexaenoic acid in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. 17(S)-HDHA could be produced by enzymatic oxidation of DHA using soybean lipoxygenase (LO) and is the putative product of mammalian 15-LOs. 17(S)-HDHA was shown to be an inhibitor of U-46619 -induced rabbit and rat aortic smooth muscle contraction with IC50 values of 4.9 and 7.2 μM, respectively. (±)17-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid.
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Description | (±)17-HDHA is an autoxidation product of docosahexaenoic acid in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. 17(S)-HDHA could be produced by enzymatic oxidation of DHA using soybean lipoxygenase (LO) and is the putative product of mammalian 15-LOs. 17(S)-HDHA was shown to be an inhibitor of U-46619 -induced rabbit and rat aortic smooth muscle contraction with IC50 values of 4.9 and 7.2 μM, respectively. (±)17-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid. |
Molecular Weight | 344.495 |
Formula | C22H32O3 |
CAS No. | 90780-52-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMF: Miscible
DMSO: Miscible
Ethanol: Miscible
0.1 M Na2CO3: 2 mg/mL
PBS (pH 7.2): 0.8 mg/mL
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(±)17-HDHA 90780-52-2 (±)17 HDHA 17-HDHA (±)17HDHA inhibitor inhibit