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(+)-Theta-cypermethrin
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Catalog No. T219197 Copy Product Info
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(+)-Theta-cypermethrin is a stereoisomer of Cypermethrin that can penetrate the blood-brain barrier and exhibits high affinity binding with AKT1, SRC, STAT3, and EGFR. It reduces delayed rectifier potassium channel current amplitude, causing a shift in the steady-state activation curve toward more negative potentials. At higher concentrations, it also shifts the steady-state inactivation curve negatively. Additionally, (+)-Theta-cypermethrin can induce abnormal electrical activity in rat hippocampal neurons and is associated with chronic respiratory system damage and neurotoxicity.
(+)-Theta-cypermethrin
Cas No. 65732-07-2
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | (+)-Theta-cypermethrin is a stereoisomer of Cypermethrin that can penetrate the blood-brain barrier and exhibits high affinity binding with AKT1, SRC, STAT3, and EGFR. It reduces delayed rectifier potassium channel current amplitude, causing a shift in the steady-state activation curve toward more negative potentials. At higher concentrations, it also shifts the steady-state inactivation curve negatively. Additionally, (+)-Theta-cypermethrin can induce abnormal electrical activity in rat hippocampal neurons and is associated with chronic respiratory system damage and neurotoxicity. |
| In vitro | (+)-Theta-cypermethrin, when applied via perfusion at concentrations ranging from 1 to 100 nM during electrophysiological recording, can inhibit the delayed rectifier potassium current (I k) in rat hippocampal CA3 neurons in a concentration-dependent manner in vitro. At a concentration of 100 nM, it can reduce the amplitude of I k by up to 53.28%, shift the steady-state activation and inactivation curves towards more negative potentials, and decrease the slope factor of the activation curve. |
| Molecular Weight | 416.30 |
| Formula | C22H19Cl2NO3 |
| Cas No. | 65732-07-2 |
| Smiles | C(O[C@H](C#N)C1=CC(OC2=CC=CC=C2)=CC=C1)(=O)[C@@H]3[C@@H](C=C(Cl)Cl)C3(C)C |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Related Tags: (+)-Theta-cypermethrin in vitro | (+)-Theta-cypermethrin formula | (+)-Theta-cypermethrin molecular weight
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