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Nicoxamat
(Synonyms: N-Hydroxynicotinamide) Copy Product Info
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Synonyms: N-Hydroxynicotinamide
Catalog No. T218565 Copy Product Info
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Nicoxamat (N-Hydroxynicotinamide) is an inhibitor of HCV and a selective inhibitor of HDAC6. It is utilized in studies related to hepatitis C virus (HCV) infection.
Nicoxamat
Cas No. 5657-61-4
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Nicoxamat (N-Hydroxynicotinamide) is an inhibitor of HCV and a selective inhibitor of HDAC6. It is utilized in studies related to hepatitis C virus (HCV) infection. |
| In vitro | Nicoxamat (compound IIa) inhibits the proliferation of HCV replicons in Huh7 luc/neo cells with an EC₅₀ of 25 μM, and a CC₅₀ of 450 μM, resulting in a selectivity index of 18. At concentrations ranging from 20-100 μM, Nicoxamat induces concentration-dependent hyperacetylation of α-tubulin in these cells. However, at 100 μM over 72 hours, it does not significantly acetylate histone H3, indicating selectivity for Class I HDAC. Additionally, within the same concentration range (0-100 μM), Nicoxamat demonstrates a concentration-dependent ability to inhibit HCV replicons and HDAC6 activity, with its antiviral effect being stronger than its HDAC6 inhibition at lower concentrations. |
| Synonyms | N-Hydroxynicotinamide |
| Molecular Weight | 138.12 |
| Formula | C6H6N2O2 |
| Cas No. | 5657-61-4 |
| Smiles | O=C(NO)C=1C=NC=CC1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: Nicoxamat in vitro | Nicoxamat formula | Nicoxamat molecular weight
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