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E0714
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Catalog No. T218376 Copy Product Info
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E0714 is a blood-brain barrier-permeable, selective Kv7.2 potassium channel activator, with EC50 values of 1.90 μM for the homomeric Kv7.2 channel and 0.021 μM for the heteromeric Kv7.2/7.3 channel. It exhibits anticonvulsant activity and is applicable in epilepsy-related research.
E0714
Cas No. 1359358-36-3
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | E0714 is a blood-brain barrier-permeable, selective Kv7.2 potassium channel activator, with EC50 values of 1.90 μM for the homomeric Kv7.2 channel and 0.021 μM for the heteromeric Kv7.2/7.3 channel. It exhibits anticonvulsant activity and is applicable in epilepsy-related research. |
| Targets & IC50 | Kv7.2 channel:1.90 μM (EC50) |
| In vitro | E0714 potently and selectively activates both the wild-type Kv7.2 homomeric channels and Kv7.2/Kv7.3 heteromeric channels, with an EC50 for activation of Kv7.2 currents at 1.90 ± 0.70 μM. |
| In vivo | E0714, administered intraperitoneally at doses ranging from 1.25 to 20 mg/kg, exhibits a dose-dependent reduction in seizure severity induced by pentylenetetrazole (PTZ) in KM mice. It also provides dose-dependent protection against MES-induced seizures in KM mice, achieving an ED50 of 2.45 mg/kg and complete protection at a 20 mg/kg dose. Additionally, E0714, given at the same dosages once daily for three consecutive days, decreases the incidence and duration of seizures induced by 6 Hz stimulation in C57BL/6J mice, with an ED50 of 3.56 mg/kg. |
| Molecular Weight | 347.37 |
| Formula | C20H17N3O3 |
| Cas No. | 1359358-36-3 |
| Smiles | O=C(NC1=CC=C(C=C1)N2C=CC=C(C(=O)NC)C2=O)C=3C=CC=CC3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: E0714 in vivo | E0714 in vitro | E0714 formula | E0714 molecular weight
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