Dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium chloride

Dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium chloride is a quaternary ammonium silane monomer used as a disinfectant and antimicrobial agent. Dimethyloctadecylammonium chloride exhibits bactericidal activity against both Gram-positive and Gram-negative bacteria and demonstrates antifungal activity against Candida albicans in solution. It can form a hydrophobic glass coating that maintains bactericidal properties against Gram-positive and Gram-negative bacteria, though its antifungal efficacy against Candida albicans is limited.

Dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium chloride is effective as a bactericide against Staphylococcus aureus (MIC = 3.9 μg/mL, MBC = 3.9 μg/mL) and Escherichia coli (MIC = 62.5 μg/mL, MBC = 62.5 μg/mL), and as a fungicide against Candida albicans (MIC = 15.6 μg/mL, MFC = 62.5 μg/mL). However, at a concentration of 62.5 μg/mL over 24 hours, it exhibits high toxicity towards human dermal fibroblasts, HaCaT keratinocytes, and HEK293 cells. When applied as a 10 mg/mL coating on glass coverslips and Lava™ Ultimate dental restorative material, it demonstrates strong antibacterial activity against Staphylococcus aureus and Escherichia coli, but shows negligible activity against Candida albicans.