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PEG300

Name: PEG300
Brand: TargetMol
SKU: T7022
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7022Cas No. 25322-68-3

Alias Polyethylene glycol 300

PEG300 (Polyethylene glycol 300) is a polymer formed from repeating units of ethylene glycol that is water soluble, low immunogenicity, and biocompatible. PEG300 is a neutral polymer with a molecular weight of 300.

PEG300

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Catalog No. T7022Alias Polyethylene glycol 300Cas No. 25322-68-3

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mL	$48	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:mw~300

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COA

Product Introduction

Bioactivity

Description	PEG300 (Polyethylene glycol 300) is a polymer formed from repeating units of ethylene glycol that is water soluble, low immunogenicity, and biocompatible. PEG300 is a neutral polymer with a molecular weight of 300.
In vitro	METHODS: Human colorectal adenocarcinoma cells Caco-2 were treated with PEG300 (30 w/v% in 100 μL) for 30 min, and cell growth inhibition was detected by MTT. RESULTS: PEG300 treatment severely reduced cell viability, and the cell survival rate was only 20%. [1]
In vivo	METHODS: To study the effect of Dasatinib on diabetic cardiomyopathy, Dasatinib (5 mg/kg in 10% DMSO + 90% PEG-300) was administered by gavage to BKS.Cg-+Leprdb/+Leprdb/OlaHsd (db/db) mice once a week for four weeks. RESULTS: Dasatinib counteracted obesity in the heart and bone marrow as well as cardiac fibrosis. [2] METHODS: To test the in vivo effects of treatment with ALW-II-41-27 (an EPHA2 inhibitor) and/or cetuximab, cetuximab (25 mg/kg in 10% 1-methyl-2-pyrrolidinone + 90% PEG 300 twice weekly) and ALW-II-41-27 (30 mg/kg/day) were injected intraperitoneally into balb/c athymic (nu+/nu+) mice bearing human colorectal adenocarcinoma tumor HCT15 for six weeks. RESULTS: The combination of ALW-II-41-27 and cetuximab significantly inhibited tumor growth. [3]
Synonyms	Polyethylene glycol 300

Chemical Properties

Molecular Weight	722.863
Formula	C₃₂H₆₆O₁₇
Cas No.	25322-68-3
Smiles	OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO
Relative Density.	1.1 g/cm3. Temperature:30 °C.
Color	Transparent
Appearance	Liquid

Storage & Solubility Information

Storage

-20°C for 2 years, 4°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100.00 mg/mL (138.34 mM), Sonication is recommended.

H2O: 50.00 mg/mL (69.17 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3834 mL	6.9169 mL	13.8339 mL	69.1694 mL
5 mM	0.2767 mL	1.3834 mL	2.7668 mL	13.8339 mL
10 mM	0.1383 mL	0.6917 mL	1.3834 mL	6.9169 mL
20 mM	0.0692 mL	0.3458 mL	0.6917 mL	3.4585 mL
50 mM	0.0277 mL	0.1383 mL	0.2767 mL	1.3834 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0138 mL	0.0692 mL	0.1383 mL	0.6917 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

The above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

polymerPolyethylene glycol-300Polyethylene glycol300PEG-300PEG300PEG 300markerInhibitorinhibitimmunogenicgastrointestinalbiocompatible