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PEG300

Catalog No. T7022 CAS 25322-68-3

Synonyms: Polyethylene glycol 300

PEG300 (Polyethylene glycol 300) is a polymer formed from repeating units of ethylene glycol that is water soluble, low immunogenicity, and biocompatible. PEG300 is a neutral polymer with a molecular weight of 300.

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PEG300, CAS 25322-68-3

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100 mL	In stock	$ 48.00

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Purity: N/A

Purity: FW~300

Purity: mw~300

Biological Description

Chemical Properties

Storage & Solubility Information

Description	PEG300 (Polyethylene glycol 300) is a polymer formed from repeating units of ethylene glycol that is water soluble, low immunogenicity, and biocompatible. PEG300 is a neutral polymer with a molecular weight of 300.
In vitro	METHODS: Human colorectal adenocarcinoma cells Caco-2 were treated with PEG300 (30 w/v% in 100 μL) for 30 min, and cell growth inhibition was detected by MTT. RESULTS: PEG300 treatment severely reduced cell viability, and the cell survival rate was only 20%. [1]
In vivo	METHODS: To study the effect of Dasatinib on diabetic cardiomyopathy, Dasatinib (5 mg/kg in 10% DMSO + 90% PEG-300) was administered by gavage to BKS.Cg-+Leprdb/+Leprdb/OlaHsd (db/db) mice once a week for four weeks. RESULTS: Dasatinib counteracted obesity in the heart and bone marrow as well as cardiac fibrosis. [2] METHODS: To test the in vivo effects of treatment with ALW-II-41-27 (an EPHA2 inhibitor) and/or cetuximab, cetuximab (25 mg/kg in 10% 1-methyl-2-pyrrolidinone + 90% PEG 300 twice weekly) and ALW-II-41-27 (30 mg/kg/day) were injected intraperitoneally into balb/c athymic (nu+/nu+) mice bearing human colorectal adenocarcinoma tumor HCT15 for six weeks. RESULTS: The combination of ALW-II-41-27 and cetuximab significantly inhibited tumor growth. [3]

Synonyms	Polyethylene glycol 300
Molecular Weight	300
CAS No.	25322-68-3

Storage

store at 4°C

Solubility Information

DMSO: 100 mg/mL (333.33 mM), Sonication is recommended.

H2O: 50 mg/mL (166.67 mM)

References and Literature

1. Pham Le Khanh H, et al. Comparative Investigation of Cellular Effects of Polyethylene Glycol (PEG) Derivatives. Polymers (Basel). 2022 Jan 11;14(2):279. 2. Gu Y, et al. The tyrosine kinase inhibitor Dasatinib reduces cardiac steatosis and fibrosis in obese, type 2 diabetic mice. Cardiovasc Diabetol. 2023 Aug 17;22(1):214. 3. Martini G, et al. EPHA2 Is a Predictive Biomarker of Resistance and a Potential Therapeutic Target for Improving Antiepidermal Growth Factor Receptor Therapy in Colorectal Cancer. Mol Cancer Ther. 2019 Apr;18(4):845-855.

Citations

1. Hu Y, Wen Q, Cai Y, et al. Alantolactone induces concurrent apoptosis and GSDME-dependent pyroptosis of anaplastic thyroid cancer through ROS mitochondria-dependent caspase pathway. Phytomedicine. 2022: 154528. 2. Guo Y, Zhu L, Duan Y, et al.Ruxolitinib induces apoptosis and pyroptosis of anaplastic thyroid cancer via the transcriptional inhibition of DRP1-mediated mitochondrial fission.Cell Death & Disease.2024, 15(2): 125.

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

Step One: Enter information below

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Step Two: Enter the in vivo formulation

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

PEG300 25322-68-3 Others immunogenic Polyethylene glycol300 biocompatible PEG 300 Polyethylene glycol 300 marker gastrointestinal inhibit polymer PEG-300 Inhibitor Polyethylene glycol-300 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.