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Obidoxime dichloride

Catalog No. T16372 CAS 114-90-9

Obidoxime dichloride, a selective oxime agent, effectively reactivates sarin-inhibited acetylcholinesterase (AChE) and mitigates the acute toxicity associated with sarin exposure. It is also utilized as an antidote for organophosphate nerve agent poisoning.

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Obidoxime dichloride, CAS 114-90-9

Pack Size	Availability	Price/USD
100 mg	35 days	$ 158.00
250 mg	35 days	$ 370.00
500 mg	35 days	$ 698.00
1 g	35 days	$ 1,160.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Obidoxime dichloride, a selective oxime agent, effectively reactivates sarin-inhibited acetylcholinesterase (AChE) and mitigates the acute toxicity associated with sarin exposure. It is also utilized as an antidote for organophosphate nerve agent poisoning.
In vivo	After administration of sarin, Obidoxime dichloride (intramuscular injection; 10 mg/kg; after 60 mins) shows a LD50 of 57.7 mg/kg. It decreases acute toxicity of sarin was evaluated.

Molecular Weight	323.76
Formula	C14H16ClN4O3
CAS No.	114-90-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Kassa J,et al. A comparison of the reactivating and therapeutic efficacy of two novel bispyridinium oximes (K727, K733) with the oxime HI-6 and obidoxime in sarin-poisoned rats and mice.Toxicol Mech Methods. 2015 Mar;25(3):229-33.

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Obidoxime dichloride 114-90-9 Others Obidoxime Obidoxime Dichloride inhibitor inhibit

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