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Methysergide maleate

Catalog No. T21423 CAS 129-49-7

Synonyms: Deseril, Sansert, UML 491, UML491, Methysergide, UML-491

Methysergide is used for prophylaxis of migraine headaches/cluster headaches but is no longer recommended due to retropulmonary/retroperitoneal fibrosis. It may also be used in the treatment of serotonin syndrome. It is also used in carcinoid syndrome to treat severe diarrhea.

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Methysergide maleate, CAS 129-49-7

Pack Size	Availability	Price/USD
1 mg	35 days	$ 78.00
5 mg	35 days	$ 273.00
10 mg	35 days	$ 423.00
25 mg	35 days	$ 953.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	Deseril, Sansert, UML 491, UML491, Methysergide, UML-491
Molecular Weight	469.54
Formula	C25H31N3O6
CAS No.	129-49-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Soluble

H2O: Insoluble

References and Literature

1. Valic M, Pecotic R, Pavlinac Dodig I, Valic Z, Stipica I, Dogas Z. Intermittent hypercapnia-induced phrenic long-term depression is revealed after serotonin receptor blockade with methysergide in anaesthetized rats. Exp Physiol. 2016 Feb 1;101(2):319-31. doi: 10.1113/EP085161. Epub 2015 Dec 20. PubMed PMID: 26621042. 2. David RB, Roncari CF, Lauar MR, Vendramini RC, Antunes-Rodrigues J, Menani JV, De Luca LA Jr. Sodium intake, brain c-Fos protein and gastric emptying in cell-dehydrated rats treated with methysergide into the lateral parabrachial nucleus. Physiol Behav. 2015 Nov 1;151:111-20. doi: 10.1016/j.physbeh.2015.07.014. Epub 2015 Jul 11. PubMed PMID: 26171591. 3. Andréjak M, Szymanski C, Maréchaux S, Arnalsteen E, Gras V, Rémadi JP, Tribouilloy C. Valvular heart disease associated with long-term treatment by methysergide: a case report. Therapie. 2014 May-Jun;69(3):255-7. doi: 10.2515/therapie/2014030. Epub 2014 Jun 18. PubMed PMID: 24934823. 4. Matsuta Y, Schwen Z, Mally AD, Shen B, Wang J, Roppolo JR, de Groat WC, Tai C. Effect of methysergide on pudendal inhibition of micturition reflex in cats. Exp Neurol. 2013 Sep;247:250-8. doi: 10.1016/j.expneurol.2013.05.006. Epub 2013 May 18. PubMed PMID: 23688680; PubMed Central PMCID: PMC3742625.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Methysergide maleate 129-49-7 Deseril, Sansert UML 491 UML491 Methysergide Methysergide Maleate UML-491 inhibitor inhibit

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